[Antibiotic therapy regimens for mild community-acquired pneumonia in patients with risk factors for ineffective treatment: clinical and economic comparisons].

Aim: To evaluate the clinical efficiency, tolerance, and pharmacoeconomic parameters of treatment for mild community-acquired pneumonia (CAP) in patients with risk factors for ineffective treatment with levofloxacin (Glevo) versus original levofloxacin and standard pharmacotherapy regimens for mild pneumonia (real practice).

Subjects And Methods: An open-label comparative randomized trial was conducted in parallel groups of 147 patients aged > or = 18 years with mild CAP and risk factors for ineffective treatment. Group 1 included 61 patients (59 men and 2 women; mean age 23.

Structural basis for promiscuity and specificity during Candida glabrata invasion of host epithelia.

The human pathogenic yeast Candida glabrata harbors more than 20 surface-exposed, epithelial adhesins (Epas) for host cell adhesion. The Epa family recognizes host glycans and discriminates between target tissues by their adhesin (A) domains, but a detailed structural basis for ligand-binding specificity of Epa proteins has been lacking so far. In this study, we provide high-resolution crystal structures of the Epa1A domain in complex with different carbohydrate ligands that reveal how host cell mucin-type O-glycans are recognized and allow a structure-guided classification of the Epa family into specific subtypes.

[Radiation thermometry used in the study of normal kidney functional activity].

In this paper, the results of use of active radiation heat flowmetry in the nephrological clinic are presented. Employment of rationalized loading tests permitted direct relationship to be established of radiation heat losses from the surface of the "open" kidney to the status of renal functions. Patterns of changes in the infrared radiation intensity have been ascertained in health and in the blockade of canalicular reabsorption.

Computer analysis of drug therapy in cardiac patients. Preliminary communication.

The authors present a system of computer control in drug therapy of cardiac patients aimed at preventing complications and adverse interactions of simultaneously administered drugs. The system includes data on the 196 most frequently used cardiac drugs and 433 other drugs showing clinically important interactions with cardiac drugs.