[Liver phospholipids composition and activity of glutathione redox-system in rats on prolonged high-fat diet].

We studied liver phospholipid composition and activity of the glutathione redox-system in rats on prolonged for 180 days high-fat diet. The adaptive response was formed from day 30 to day 90 of high-fat load and was associated with increased relative content of phosphatidylseryne and phosphatidylethanolamine homeostasis. Constant antioxidant activity of glutathione redox-system for 30 days period of high-fat load was achieved by stable glutathioneperoxidase activity, on 90th day--level of glutathione reductase increased.

[The regulatory role of the oxide nitrogen and monoxide carbon under oxidative stress in experimental dyslipidemia].

The condition of the system "prooxidants-antioxidants" in dynamic model alimentary dyslipidemia in Vistar rats of the lines were studied. General antioxidant activities, activities of antioxidant enzymes (katalase, glutathione reductase, glutathione peroxidase), levels of glutathione, products of lipoperoxides in blood and liver, intensive forming of the oxide nitrogen and monoxide carbon were investigated. The role of the signal molecules (oxide nitrogen and monoxide carbon) in regulation oxidative stress was discussed.

[Metabolic disorders in patients with chronic obstructive pulmonary disease].

Aim: To characterize cell dysregulation in chronic obstructive pulmonary disease (COPD) at local and systemic levels.

Material And Methods: A total of 48 patients with COPD were examined (mean disease duration 11.2 +/- 7.

[Experimental-clinical substantiation of the diet therapy with zosterin in kidney diseases].

The results of enterosorbent of marine origin zoosterol application under nephropathy are cited. Detoxicational, lipid corregated action of zoosterol was revealed as a result of experimental researches on nephrocalcinosis model, but calcium accumulation was observed in animals' kidney tissue. Clinical examinations including zoosterol application and dietotheraphy showed the decreasing of heightened calcium level in serum and urine, cholesterol and triglycerides, stabilization of membranodestructive processes in urinary excretive system for patients with chronic pyelonephritic.

[Age-related changes of lipid spectrum, level of lipid peroxidation, and antioxidant defence in the liver and blood of rats].

It has been shown that the lowest level of total lipids, cholesterol, triacylglycerols and products of lipid peroxidation of blood and liver, as a rule, is specific to adult rats. These characteristics are significantly higher for old and young animals. At the same time, the level of glutathione and alphatocopherols in adults' liver is much higher than in young and old rats.