[Peptidergic modulation of the hippocampus synaptic activity].

Effects of two newly synthesized nootropic and anxiolytic dipeptides: Noopept and Selank on inhibitory synaptic transmission in hippocampal CA1 pyramidal cells were investigated using patch-clamp technique in whole-cell configuration. Bath application of Noopept (1 microM) or Selank (2 microM) significantly increased the frequency of spike-dependent spontaneous m1PSCs, whereas spike-independent mlPSCs remained unchanged. It was suggested that both peptides mediated their effect sue to activation of inhibitory interneurons terminating on CA1 pyramidal cells.

[Long-term pathomorphologic changes in the neurons of the rat brain following irradiation with carbon ions and gamma rays].

Quantitative and qualitative morphological changes in neurons and glia of rat brain were studied one month after exposure to accelerated carbon ions 4 GeV/nucleon (LET-76 MeV cm2.r-1) and gamma-radiation (137Cs, 0.25 to 4.

[Incidence of morphologic changes in cerebral cortex neurons of the rat exposed to accelerated carbon ions].

Structural lesions in neurons of the brain cortex of rats were investigated 1 and 3 months after their exposure to accelerated carbon ions with the energy 320 MeV/nuclon 10(4) particles/cm2 (LET = 120 MeVcm2/g) as well as to gamma-radiation in the dose 1.0 Gy. The irradiated animals showed morphofunctional, dystrophic and reparative lesions in neurons.

[Various characteristics of morphological changes in the brain in newborn infants with intrauterine and perinatal damage of the central nervous system].

Pathomorphological examination of the brain was carried out in 8 infants with severe forms of perinatal encephalopathy who died on the 17-th-25th day of life from intercurrent diseases. The investigation revealed a combination of circulatory disorders, dystrophic changes in neurons, fibers, and glia as well as focal productive inflammation of the medulla (predominantly in the area of lateral ventricle walls). An original technique was developed for the determination of the volumetric density of Betz's cells.