Publications by authors named "V I D Ros"
Since the discovery of the first-generation ALK inhibitor, many other tyrosine kinase inhibitors have been demonstrated to be effective in the first line or further lines of treatment in patients with advanced non-small cell lung cancer with EMLA4-ALK translocation. This review traces the main milestones in the treatment of ALK-positive metastatic patients and the survival outcomes in the first-line and second-line settings with different ALK inhibitors. It presents the two options available for first-line treatment at the present time: sequencing different ALK inhibitors versus using the most potent inhibitor in front-line treatment.
View Article and Find Full Text PDFBackground: Data about the safety and the efficacy of flow diversion for distal anterior cerebral artery (DACA) aneurysms are limited. We present the largest multicenter analysis evaluating the outcomes of flow diversion in unruptured DACA aneurysm treatment.
Methods: Databases from 39 centers were retrospectively reviewed for unruptured DACA aneurysms treated with flow-diverting stents.
Objective: To build a supervised machine learning (ML) model that selects the best first-line treatment strategy for unruptured bAVMs.
Methods: A Randomized Trial of Unruptured Brain Arteriovenous Malformations (ARUBA) trial data was obtained from the National Institute of Neurological Disorders and Stroke (NINDS). A team of five clinicians examined the demographic, clinical, and radiological details of each patient at baseline and reached a consensus on the best first-line treatment for bAVMs.
Article Synopsis
- - The study investigates the reliability of Diffusion Kurtosis Imaging (DKI) parameters by comparing them with perfusion metrics from Dynamic Contrast Enhanced (DCE) and Dynamic Susceptibility Contrast (DSC) MRI techniques in primary central nervous system lymphoma (PCNSL) patients.
- - Analysis of 15 lesions from patients with Epstein-Barr Virus negative PCNSL showed significant correlations, notably between DKI parameters and both DCE/DSC metrics, suggesting that DKI adds valuable insights beyond traditional diffusion models.
- - The findings indicate a strong inverse correlation between several DKI parameters and perfusion metrics, pointing to DKI's potential to enhance understanding of tumor characteristics and inform clinical practices.
The Mediterranean fruit fly is an agricultural pest of a wide variety of fruit crops. An effective method to counteract them in the field is through the application of the sterile insect technique, which requires the mass-production of sterile males. The presence of pathogens, and specifically viruses, threatens the well-being of mass-reared insects generating an interest on the development of strategies for viral elimination or containment.
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