[Efficacy and safety of the drug Cellex for the treatment of patients with cognitive impairment with chronic cerebral ischemia - results of a multicenter randomized double-blind placebo-controlled clinical trial].

Objective: To evaluate the efficacy and safety of using Cellex for the treatment of cognitive impairment as part of the complex therapy of patients with chronic cerebral ischemia (CCI) compared with placebo.

Material And Methods: The study randomized 300 patients with a reliable diagnosis of CCI stage 1-2, all participants were divided into two groups, 150 participants in each - main and control. The study drug Cellex or placebo was administered as two 10-day treatment courses, 1 ml once a day.

[Meiotic drive in mice carrying t-complex in their genome].

The deviation of alleles and chromosomes from Mendelian inheritance is characteristic of the meiotic drive. This review describes the mechanism in question using the best-studied example of transmitted ratio distortion in the heterozygous male mice carrying t-haplotypes. The t-complex is best model for studying the meiotic drive under laboratory conditions.

[Characteristics of serum albumin in patients with intracerebral hemorrhagic stroke].

Authors studied the influence of the psychoemotional stress preceding the stroke on the dynamics of neurological symptoms (Glasgo coma scale, Scandinavian stroke scale and Barthel index) and on the conformational changes of albumin in 59 patients with intracerebral hemorrhage due to arterial hypertension. The psychoemotional stress was associated with less favorable clinical course and outcome of intracerebral hemorrhage. Conformational properties of albumin were changed in all patients with intracerebral hemorrhage compared to controls.

[Neuroprotective treatment with citicoline (ceraxon) in patients with ischemic stroke].

The dynamics of neurological symptoms assessed with the Scandinavian stroke scale, the Barthel index and the modified Rankin scale was studied in 89 patients with moderate ischemic stroke who received citicoline (ceraxone) intravenously and orally. The results were compared to a group of 52 age-, sex- and stroke-matched patients who did not receive citicoline. To the date of discharge from the hospital (days 21-24), the full restoration (p<0.

[The epigenetic mechanism of the effect of mildly deleterious mutations on the viability of the progeny and their correction in meiosis].

Data supporting the hypothesis about the epigenetic nature of deleterious mutations leading to the death of a part of the progeny are presented. It is assumed that during the life cycle "mutant" variants of formation of structural-functional loop domains occur in chromosomes that normally are corrected during meiosis. An abnormal loop changes the activity of many tens of genes, both increasing (+) and decresing (-) it, which affects the viability of homozygotes and to a lesser extent the viability of heterozygotes.