Publications by authors named "V Huang"
Reactogenicity, the occurrence of vaccine side effects, can impact vaccine acceptance. There is limited data comparing the reactogenicity of COVID-19 vaccines to other routinely used vaccines, such as the meningococcal conjugate vaccine (MenACWY). In a trial of UK adults, participants received a third COVID-19 vaccine dose (NVX-CoV2373, BNT162b2, or mRNA1273) alongside MenACWY as an active control.
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- * The huR83C mouse model replicates the disease phenotype and has been used to test the effectiveness of BEAM-301, a treatment that utilizes lipid nanoparticles and adenine base editing to correct the harmful G6PC1-R83C variant.
- * BEAM-301 has shown the ability to correct about 60% of the variant in liver cells, restore blood sugar control, improve overall health, and increase survival rates in mice, indicating its potential as a therapeutic option for patients with this specific genetic mutation
Background: Tumor Necrosis Factor (TNF) are expressed in milk. Experimental data indicate enhanced brain growth and cognitive development in the mouse offspring given milk deficient in TNF and TNF-dependent chemokines. Although monoclonal antibodies against TNF (TNFmAb) are used during breastfeeding due to minimal milk excretion, whether it affects endogenous TNF levels in human milk is unclear.
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- The study aimed to evaluate the effectiveness of new protocols for using speaking valves (SV) in patients with tracheostomies at a major medical center, focusing on increasing usage and reducing wait times for trials.
- A retrospective analysis of 421 patients showed that after implementing these protocols, the percentage of eligible patients trying SV increased from 75% to 95%, and those succeeding on their first attempt rose from 60% to 75%.
- The findings suggest that the new protocols led to an 80% reduction in the time required for SV placement, highlighting the need for continued improvements in tracheostomy care practices.
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- The IDEOM Vitiligo Workgroup aims to create a standardized approach for reporting the severity of vitiligo, as current methods are inconsistent and lack uniformity.
- A literature review identified 50 clinical trials focusing on topical treatments for vitiligo, revealing various grading systems for measuring repigmentation and quality of life.
- The study suggests employing metrics like body surface area scoring and the Vitiligo Area Scoring Index to improve data collection, while also considering new factors like treatment burden and cost-effectiveness.