Risk Factors for All-Cause Mortality in Patients Diagnosed with Advanced Heart Failure: A Scoping Review.

Identifying the evolving needs of patients with advanced heart failure (AdHF) and triaging those at high risk of death can facilitate timely referrals to palliative care and advance patient-centered individualized care. There are limited models specific for patients with end-stage HF. We aim to identify risk factors associated with up to three-year all-cause mortality (ACM) and describe prognostic models developed or validated in AdHF populations.

Integrating marine debris into socioeconomic monitoring: Informing local actions in Minicoy Island, India and charting a new global approach.

In 2019, the authors introduced the topic of anthropogenic marine debris into the Global Socioeconomic Monitoring Initiative for Coastal Management (SocMon) during an assessment conducted at Minicoy Island in India. SocMon is a process-based approach and set of tools for conducting community-based socio-economic monitoring of changes in coastal communities that has been adopted and adapted worldwide through the Global SocMon network. It provides an experiential learning opportunity that often leads to community driven action.

Marine litter in the Red Sea: Status and policy implications.

The Red Sea's unique ecosystem is home to >1500 species. However, the presence of anthropogenic litter, whether from land-based or sea-based sources, may pose a potential risk to the Red Sea fauna and flora. This work analyzes marine litter in the Red Sea, utilizing the Drivers-Pressure-State-Impact-Response (DPSIR) framework to group findings in a survey of peer-reviewed studies.

Liver colonization by human colon cancer cells is reduced by antisense inhibition of MUC2 mucin synthesis.

Background & Aims: Alterations in the production of epithelial mucins have been correlated with advanced tumor stage in the colon, but direct evidence for a role of specific mucin genes in liver metastasis is lacking. The current study was designed to establish more directly the role of MUC2 in colon cancer metastasis.

Methods: MUC2 levels were manipulated in highly metastatic human colon cancer cells using eukaryotic expression constructs designed to express a portion of MUC2 complementary DNA in antisense orientation.