Publications by authors named "V Helfinger"
Genetic deletion of Nox4 enhances cancerogen-induced formation of solid tumors.
Proc Natl Acad Sci U S A
March 2021
Article Synopsis
- Reactive oxygen species (ROS) are known for causing cellular damage and cancer, but they also play a crucial role in cellular signaling and maintaining homeostasis, particularly through the action of NADPH oxidase 4 (Nox4).
- Research using mouse models revealed that deleting Nox4 increases tumor formation and reduces the ability to recognize DNA damage, as it disrupts the phosphorylation of γH2AX, a key marker for DNA damage.
- Nox4 maintains low levels of the phosphatase PP2A in the nucleus, which is essential for effective DNA damage surveillance; without it, there's enhanced AKT phosphorylation leading to uncontrolled cell proliferation and genomic instability, both of which contribute to cancer development.
Background: Cerebral vasospasm (CVS) is a frequent complication after subarachnoid hemorrhage (SAH), with no sufficient therapy and a complex pathophysiology.
Objective: To explore the vitamin D system as a potential treatment for CVS.
Methods: 25-vitamin D3 levels tested between 2007 and 2015 and data of SAH patients admitted during the months with a peak vs nadir of VitD3 values were analyzed, retrospectively.
The NADPH Oxidase Nox4 Controls Macrophage Polarization in an NFB-Dependent Manner.
Oxid Med Cell Longev
January 2020
The family of NADPH oxidases represents an important source of reactive oxygen species (ROS) within the cell. Nox4 is a special member of this family as it constitutively produces HO and its loss promotes inflammation. A major cellular component of inflammation is the macrophage population, which can be divided into several subpopulations depending on their phenotype, with proinflammatory M(LPS+IFN) and wound-healing M(IL4+IL13) macrophages being extremes of the functional spectrum.
View Article and Find Full Text PDFAim: NADPH oxidase (Nox) -derived reactive oxygen species have been implicated in redox signaling via cysteine oxidation in target proteins. Although the importance of oxidation of target proteins is well known, the specificity of such events is often debated. Only a limited number of Nox-oxidized proteins have been identified thus far; especially little is known concerning redox-targets of the constitutively active NADPH oxidase Nox4.
View Article and Find Full Text PDFAim: Reactive oxygen species (ROS) produced by enzymes of the NADPH oxidase family serve as second messengers for cellular signaling. Processes such as differentiation and proliferation are regulated by NADPH oxidases. In the intestine, due to the exceedingly fast and constant renewal of the epithelium both processes have to be highly controlled and balanced.
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