Publications by authors named "V H Patterson"
Purpose: The AMPLIFY trial recently established fixed-duration acalabrutinib, venetoclax, and obinutuzumab (AVO) as a new standard-of-care option for patients with previously untreated chronic lymphocytic leukemia (CLL) with wild-type ; however, due to the chemoimmunotherapy control arm, AMPLIFY excluded patients with high-risk aberration, for whom current standards of care are continuous Bruton tyrosine kinase inhibitor therapy or alternatively fixed-duration venetoclax-based doublets. AVO has not previously been evaluated in patients with CLL with aberration.
Methods: This investigator-sponsored, multicenter, phase II study enrolled patients with treatment-naïve CLL enriched for high-risk CLL, defined by aberration (ClinicalTrials.
Article Synopsis
- Several trials have shown that adversity-focused treatments can reduce symptoms of PTSD and psychosis, but there is limited research on their effects on substance use, especially in early phase psychosis populations.
- This study tested an adapted prolonged exposure therapy (PE+) on 19 adults with psychotic disorders and substance misuse, assessing multiple outcomes before and after treatment.
- Results indicated significant improvements in some adversity-related areas and participant satisfaction, but there was no overall improvement in psychotic symptoms and substance misuse actually increased for some individuals.
Congenital heart defects are leading causes of neonatal mortality and are often associated with placental abnormalities, but mechanisms linking placenta and heart development are poorly understood. Herein, we investigated a potential signaling network connecting the placenta and nascent heart in mice. We found that fetal hearts exposed to media conditioned by placental tissue or differentiated wild-type trophoblast stem (TS) cells, but not undifferentiated TS cells, showed increased heart rate and epicardial cell outgrowth.
View Article and Find Full Text PDFPurpose: Epilepsy type, whether focal or generalised, is important in deciding anti-seizure medication (ASM). In resource-limited settings, investigations are usually not available, so a clinical separation is required. We used a naïve Bayes approach to devise an algorithm to do this, and compared its accuracy with algorithms devised by five other machine learning methods.
View Article and Find Full Text PDFBackground: While most research has largely focused on medical risks associated with reduced health-related quality of life (HRQOL) in survivors, sociodemographic and family factors may also play a role. Thus, we longitudinally examined sociodemographic factors and family factors associated with survivor HRQOL, including adolescent's cancer-specific stress, mother's general stress, and mother-adolescent communication.
Methods: Mothers (N = 80) and survivors (ages 10-23, N = 50) were assessed 5 years following initial diagnosis.