Hearing in Two Closely Related Species ( and ).

The genus has been extensively used as a model for ecological, behavioral, and evolutionary investigations. We used auditory brainstem responses (ABRs), craniofacial morphology, and pinna measurements to compare characteristics that impact hearing in two wild-caught species, . We observed significant statistical differences in craniofacial and pinna attributes between species with overall exhibiting larger features than .

SOPRANO: Macitentan in patients with pulmonary hypertension following left ventricular assist device implantation.

Macitentan is a dual endothelin receptor antagonist (ERA) approved for treating pulmonary arterial hypertension (PAH). SOPRANO evaluated the efficacy and safety of macitentan versus placebo in pulmonary hypertension (PH) patients after left ventricular assist device (LVAD) implantation. SOPRANO was a phase 2, multicenter, double-blind, randomized, placebo-controlled, parallel-group study.

Treatment with Oral or Inhaled Treprostinil in Patients with Pulmonary Arterial Hypertension and Cardiovascular Comorbidities.

Background: An increasing number of patients with pulmonary arterial hypertension (PAH) have cardiovascular comorbidities. However, the effects of comorbidities on responses to PAH treatment are not well understood.

Research Question: Do cardiovascular comorbidities in patients with PAH influence the efficacy and tolerability of inhaled or oral treprostinil?

Study Design And Methods: All patients from phase 3 studies TRIUMPH (N = 235) and FREEDOM-EV (N = 690) were included in this post hoc analysis and were classified as having 0, ≥1, or ≥2 cardiovascular comorbidities of interest based on patients' medical histories.

Unveiling the Structural, Electronic and Magnetic Properties of GdASiO (A = K, Na, and Li) Oxides With Promising Potential for Low-Temperature Magnetic Cooling.

The growing demand for solid-state magnetic cooling, leveraging the magnetocaloric effect requires the discovery of high-performing magnetocaloric materials (MCMs). Herein, a family of Gd-containing MCMs is provided, specifically the GdASiO (A = K, Na, and Li) oxides, which demonstratse exceptional low-temperature magnetocaloric performance. Through comprehensive experimental investigations and theoretical calculations on their structural, electronic, and magnetic properties, it is unequivocally confirmed that all of them crystallize in a hexagonal apatite-type structure (space group P6/m), exhibiting an antiferromagnetic semiconductor ground state with magnetic ordering temperatures below 1.