Publications by authors named "V Gustavo Sierra Gonzalez"

Background And Objective: Serological screening for Chagas disease (CD) in Latin American adults living in Europe is a cost-effective strategy for transmission prevention. The World Health Organization recommends two different serological tests including native and recombinant antigens for IgG detection. In Spain, most commercialized native tests require manual processing.

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Organisms may simultaneously face thermal, desiccation and nutritional stress under climate change. Understanding the effects arising from the interactions among these stressors is relevant for predicting organisms' responses to climate change and for developing effective conservation strategies. Using both dynamic and static protocols, we assessed for the first time how sublethal desiccation exposure (at 16.

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Aim: To investigate the natural progression of SGCE-associated myoclonus dystonia from symptom onset in childhood to early adulthood.

Method: Myoclonus and dystonia were monitored using rating scales in two cohorts of participants from Spain and the Netherlands. Individual annualized rates of change were calculated and longitudinal trends were assessed using Bayesian mixed models.

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Multiple viruses that are highly pathogenic in humans are known to have evolved in bats. How bats tolerate infection with these viruses, however, is poorly understood. As viruses engage in a wide range of interactions with their hosts, it is essential to study bat viruses in a system that resembles their natural environment like bat-derived cellular models.

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Article Synopsis
  • - Tubo-ovarian high-grade serous carcinoma (HGSC) is a highly lethal form of cancer that often responds to platinum-based chemotherapy due to common issues with DNA damage repair pathways.
  • - Current mechanisms behind platinum resistance in HGSC are complex and not well understood, leading to a lack of effective biomarkers or treatments to improve patient outcomes.
  • - The study uses advanced single-cell mass cytometry to analyze protein responses in HGSC cells, identifying eight specific protein modules linked to carboplatin resistance and sensitivity, which could help in better categorizing and treating drug resistance in patients.
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