Publications by authors named "V Guo"
Reversible Electron-Beam Patterning of Colloidal Nanoparticles at Fluid Interfaces.
ACS Appl Mater Interfaces
December 2024
The directed self-assembly of colloidal nanoparticles (NPs) using external fields guides the formation of sophisticated hierarchical materials but becomes less effective with decreasing particle size. As an alternative, electron-beam-driven assembly offers a potential avenue for targeted nanoscale manipulation, yet remains poorly controlled due to the variety and complexity of beam interaction mechanisms. Here, we investigate the beam-particle interaction of silica NPs pinned to the fluid-vacuum interface of ionic liquid droplets.
View Article and Find Full Text PDFBackground: Despite growing evidence linking loneliness and depressive symptoms, the underlying pathways remain unclear. This study aims to assess the impact of loneliness on depressive symptoms among Chinese adolescents and investigate the potential mediating role of sleep disturbance.
Methods: A cross-sectional study was conducted between November and December 2021.
Maternal genetic variants in kinesin motor domains prematurely increase egg aneuploidy.
Proc Natl Acad Sci U S A
November 2024
Article Synopsis
- The quality of female eggs is crucial to reproductive lifespan, heavily influenced by the presence of the right number of chromosomes (euploidy), with common errors in meiosis leading to egg aneuploidy.
- Researchers used a genetic biobank to identify 404 genes associated with higher rates of egg aneuploidy, highlighting the role of the kinesin protein family in this process.
- They demonstrated that specific genetic variants in kinesin genes can cause increased aneuploidy in mouse eggs and validated that certain variants accelerate reproductive aging, paving the way for potential noninvasive biomarkers to assess egg quality in fertility medicine.
Article Synopsis
- - The female reproductive lifespan is influenced by egg quality, particularly the condition of chromosomes in eggs (euploidy) versus abnormalities (aneuploidy).
- - Researchers analyzed genetic data from mothers to pinpoint 404 genes associated with high rates of egg aneuploidy, highlighting the role of kinesin protein family genes in this risk.
- - Experimental studies in mice confirmed that specific variants in kinesin genes lead to increased egg aneuploidy and faster reproductive aging, opening up possibilities for non-invasive egg quality assessments in fertility treatments.
Ultrafast electron diffraction (UED) stands as a powerful technique for real-time observation of structural dynamics at the atomic level. In recent years, the use of MeV electrons from radio frequency guns has been widely adopted to take advantage of the relativistic suppression of the space charge effects that otherwise limit the temporal resolution of the technique. Nevertheless, there is not a clear choice for the optimal energy for a UED instrument.
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