Publications by authors named "V Guarnotta"
Article Synopsis
- The review explores the prevalence of hypercortisolism (Cushing's syndrome) in individuals with diabetes and obesity, aiming to determine if screening is needed for these populations.
- It finds that Cushing's syndrome prevalence in type 2 diabetes patients ranges from 0.6% to 9.3%, with the overnight dexamethasone suppression test being the most common but with notable false positive rates.
- The study concludes that clinical judgment is crucial for screening decisions, with the overnight dexamethasone test recommended for diabetes patients, while late-night salivary cortisol tests are also viable for obese patients.
Objective: Adrenal insufficiency (AI) is characterized by increased mortality compared to general population, mainly due to cardiovascular disease. Conventional glucocorticoid (GC) replacement therapy has a role in determining the increased mortality risk. Primary outcome of the current study was to evaluate the impact of 10 years of conventional GCs and DR-HC on body weight changes in treatment-naive patients with AI.
View Article and Find Full Text PDFIncreased frequency of microalbuminuria in patients with type 3 autoimmune polyglandular syndrome (APS) compared to isolated autoimmune type 1 diabetes mellitus: A real-life study.
Diabetes Res Clin Pract
July 2024
Article Synopsis
- - The study aimed to compare metabolic control and chronic complications between patients with type 3 autoimmune polyglandular syndrome (APS3) and those with only type 1 diabetes mellitus (T1DM).
- - Researchers analyzed data from 276 T1DM patients and 214 APS3 patients, discovering that APS3 patients had earlier autoimmune thyroid disease (AIT) onset and more frequent microalbuminuria than T1DM patients.
- - Patients with APS3 who received levothyroxine treatment had better HbA1c levels, indicating improved metabolic control compared to those who were untreated.
Adrenal Cushing's syndrome is a rare cause of endogenous hypercortisolism in neonatal and early childhood stages. The most common causes of adrenal CS are hyperfunctioning adrenal tumours, adenoma or carcinoma. Rarer causes are primary bilateral macronodular adrenal hyperplasia (PBAMH), primary pigmented adrenocortical disease (PPNAD) and McCune Albright syndrome.
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