Publications by authors named "V Guadagnuolo"
Although targeting of cell metabolism is a promising therapeutic strategy in acute myeloid leukemia (AML), metabolic dependencies are largely unexplored. We aimed to classify AML patients based on their metabolic landscape and map connections between metabolic and genomic profiles. Combined serum and urine metabolomics improved AML characterization compared with individual biofluid analysis.
View Article and Find Full Text PDFApproximately 18% of acute myeloid leukemia (AML) cases express a fusion transcript. However, few fusions are recurrent across AML and the identification of these rare chimeras is of interest to characterize AML patients. Here, we studied the transcriptome of 8 adult AML patients with poorly described chromosomal translocation(s), with the aim of identifying novel and rare fusion transcripts.
View Article and Find Full Text PDFBackground: Aneuploidy occurs in more than 20% of acute myeloid leukemia (AML) cases and correlates with an adverse prognosis.
Methods: To understand the molecular bases of aneuploid acute myeloid leukemia (A-AML), this study examined the genomic profile in 42 A-AML cases and 35 euploid acute myeloid leukemia (E-AML) cases.
Results: A-AML was characterized by increased genomic complexity based on exonic variants (an average of 26 somatic mutations per sample vs 15 for E-AML).
Article Synopsis
- Umbilical Cord Blood (UCB) is a promising alternative for patients with blood cancers who lack matched donors, and using the intrabone (IB) method may enhance outcomes due to higher cell availability.
- In a study involving 23 patients, there was a high chance of recovering blood cell counts by day 90, with low rates of severe graft-versus-host disease (GVHD) and quick immune system restoration.
- The research highlighted that the success of IB-UCB transplants could be linked to specific stem cell regulatory markers like c-Mpl, suggesting that the direct IB injection may help maintain stem cell function in a supportive environment.
Article Synopsis
- Chromothripsis is a big problem that happens to chromosomes, breaking them up and messing them up, and it was found in some patients with a type of blood cancer called acute myeloid leukemia (AML).
- In a study of 395 patients, they found that 26 had chromothripsis, which was linked to older age and certain genetic issues.
- Patients with chromothripsis didn't do as well, meaning they had shorter survival times compared to other patients, showing it's important for understanding and treating AML.