Publications by authors named "V Graziano"
The persistent murine norovirus strain MNV is a model for human norovirus and enteric viral persistence. MNV causes chronic infection by directly infecting intestinal tuft cells, rare chemosensory epithelial cells. Although MNV induces functional MNV-specific CD8 T cells, these lymphocytes fail to clear infection.
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- Scientists found out that a substance called adenosine helps certain pancreatic cancer cells avoid being attacked by the immune system, making it harder to treat the cancer with immunotherapy.
- They used special tests on mice with pancreatic cancer to study how this adenosine affects the environment around the tumor and how immune cells behave there.
- The researchers discovered that blocking adenosine can slow down tumor growth and make other cancer treatments work better by changing how immune cells are present in the tumor area.
Identification of host determinants of coronavirus infection informs mechanisms of pathogenesis and may provide novel therapeutic targets. Here, we demonstrate that the histone demethylase KDM6A promotes infection of diverse coronaviruses, including SARS-CoV, SARS-CoV-2, MERS-CoV and mouse hepatitis virus (MHV) in a demethylase activity-independent manner. Mechanistic studies reveal that KDM6A promotes viral entry by regulating expression of multiple coronavirus receptors, including ACE2, DPP4 and Ceacam1.
View Article and Find Full Text PDFMurine norovirus (MNoV) is a model for human norovirus and for interrogating mechanisms of viral tropism and persistence. We previously demonstrated that the persistent strain MNoV infects tuft cells, which are dispensable for the non-persistent strain MNoV. We now show that diverse MNoV strains require tuft cells for chronic enteric infection.
View Article and Find Full Text PDFBackground: Different oral appliances (OAs) have been proposed to control sleep bruxism (SB) detrimental effects on the stomatognathic system.
Objective: The aim of the study was to evaluate the effect of different OAs on SB activity and masticatory muscle activity (sMMA) measured by EMG.
Methods: This longitudinal cohort study was conducted on 51 patients (21 M, 30 F, mean age 26,5 ± 3,5) suffering from SB diagnosed with a validated portable EMG-ECG holter and wearing different OAs: occlusal splints, functional appliance with metallic bites and clear aligners followed after 1 week, 1 month, 3 months, 6 months and 12 months from delivery.