Publications by authors named "V Gras-Champel"
Background: We sought to comprehensively describe drug-related components associated with acute kidney injury (AKI) in patients with chronic kidney disease (CKD), describing the incidence of drug-related AKI, the proportion of preventable AKI, identified the various drugs potentially associated with it, explored the risk factors, and assessed the 1-year incidences of the recurrence of drug-related AKI, kidney failure, and death.
Methods: CKD-REIN is a French national prospective cohort of 3033 nephrology outpatients with a confirmed diagnosis of CKD (eGFR <60 ml/min/1.73 m²).
Article Synopsis
- - The study analyzes 290 cases of retinal vein and artery occlusions linked to COVID-19 vaccines in France, with most cases arising from mRNA vaccines (68% for vein occlusions) and an average onset delay of about 11-17 days.
- - Nearly half of the patients with retinal vein occlusions had existing risk factors, primarily hypertension, and only a small number experienced positive rechallenges after the vaccine.
- - Overall, while a temporal association exists between vaccinations and retinal occlusions, many cases were influenced by pre-existing health conditions, suggesting that the benefits of vaccination still outweigh the risks, particularly for mRNA vaccines.
Rationale & Objective: Adverse drug reactions (ADRs) are common in patients with chronic kidney disease (CKD). The impact of kidney function decline on serious ADR risk has been poorly investigated. We comprehensively describe ADRs and assess the relationship between estimated glomerular filtration rate (eGFR) and serious ADR risk.
View Article and Find Full Text PDFBackground: Statins are recommended in kidney transplant recipients (KTRs)-a population with a high risk of major cardiovascular (CV) events. However, the literature data on the effectiveness of statins in KTRs are sparse and inconclusive. The present study's objective was to evaluate the association between statin exposure and atherosclerotic CV events in KTRs and the biochemical effectiveness of statins on the lipid profile.
View Article and Find Full Text PDFObjectives: The subcutaneous (SC) route provides an alternative to the IV or oral route for drug administration in the elderly. The benefits of SC administration have been proven for hydration but are still debated for antibiotics because tolerance remains uncertain, especially in the frail geriatric population. Here, we aimed to improve current knowledge concerning the tolerance profile of ceftriaxone SC administration at both the systemic and cutaneous level, as well as in terms of pain.
View Article and Find Full Text PDF