Genotypic profile of Staphylococcus spp., Enterococcus spp., and E. coli colonizing dogs, surgeons, and environment during the intraoperative period: a cross-sectional study in a veterinary teaching hospital in Brazil.

Aims: This prospective cross-sectional study aimed to determine the occurrence of resistance genes and genetic diversity in Staphylococcus spp., Enterococcus spp., and Escherichia coli isolated from dogs' superficial surgical site (SS), surgeons' hands, and the operating room (OR) during the intraoperative period.

Knowledge about globin genetics for precision diagnosis of hemoglobinopathies: A case Study.

More than 1,800 changes in the synthesis and structure of hemoglobin (Hb) are estimated to exist. Many of them can be identified by chromatographic and electrophoretic analyses. However, in some cases, critical interpretation, accompanied by molecular techniques and gene sequencing, is necessary for diagnosis.

Prediction of early-onset bipolar using electronic health records.

Background: Early identification of bipolar disorder (BD) provides an important opportunity for timely intervention. In this study, we aimed to develop machine learning models using large-scale electronic health record (EHR) data including clinical notes for predicting early-onset BD.

Methods: Structured and unstructured data were extracted from the longitudinal EHR of the Mass General Brigham health system.

Nanoengineered Self-Assembling Peptides with Increased Proteolytic Stability Promote Wound Healing.

The copper complex of the tripeptide glycine-histidine-lysine (GHK) has proven benefits in wound healing and tissue remodeling by promoting blood vessel growth and increasing skin oxygen levels, but its activity is reduced in body fluids due to fast proteolytic cleavage. Herein, we designed several peptides that bear the GHK sequence and can self-assemble into supramolecular nanostructures aiming for enhanced bioactivity. The design involves a phenylalanine (F) backbone known for its ability to form supramolecular assemblies.