Phenotypic variation in the phosphotransferase activity of human red cell acid phosphatase (ACP1).

Red cell acid phosphatase (ACP1) catalyses the transfer of phosphate from phosphate ester substrates to suitable acceptor alcohols such as methanol and glycerol. The rate of substrate turnover in the presence of acceptors is increased by the increment of the phosphotransferase reaction, thus allowing this activity to be measured. There is specificity with regard to acceptors: (a) polyols (e.

Phenotype dependence in the inhibition of red cell acid phosphatase (ACP) by folates.

Red cell acid phosphatase (ACP) is shown to be inhibited by folic acid and various folates. The degree of inhibition is phenotype dependent with a pattern of variation differing from that of the well recognized variation in red cell activity levels. The pattern of variation is ordered ACP1B less than ACP1A less than ACP1C in terms of the relative allelic contributions to the observed inhibition.

Esterase D polymorphism in Chinese and Japanese.

Esterase D phenotypes have been determined in Chinese and Japanese populations in the San Francisco area. The EsD1 gene frequencies were 0.612 for the Chinese population and 0.