Publications by authors named "V Giacomet"
Background & Aims: Glecaprevir/Pibrentasvir (GLE/PIB) has been approved by the European Medicine Agency (EMA) and by the US Food and Drug Administration (US-FDA) for the treatment of children and adolescents from 3 years of age with chronic hepatitis C virus (CHC) infection. The aim of this study was to confirm the real-world effectiveness and safety of GLE/PIB in children and adolescents (3 to < 18 years old) with CHC.
Methods: This prospective, multicentre study involved 11 Italian centres.
The purpose of this narrative review is to analyze the most recent studies about the role of C-reactive protein (CRP) and procalcitonin (PCT), two of the main biomarkers of infection, in distinguishing viral from bacterial etiology, in predicting the severity of infection and in guiding antibiotic stewardship in children with community-acquired pneumonia (CAP). The studies examined reveal that both CRP and PCT play a valuable role in diagnosing pediatric CAP, though each has limitations. CRP has moderate accuracy in distinguishing bacterial from viral infections, but its elevated levels are not exclusive to bacterial infections; PCT, however, shows higher specificity for bacterial CAP, with studies confirming its ability to differentiate bacterial causes, especially in severe cases.
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- A survey was conducted among 32 senior clinicians across 20 European countries to understand current practices in postnatal prophylaxis (PNP) and infant feeding guidelines.
- Twenty-three clinicians responded, revealing that all countries use risk stratification for PNP, but methods and regimens widely differ, with zidovudine being the most commonly used drug.
- There is significant variation in guidelines regarding infant feeding for babies born to HIV-positive parents, highlighting the need for harmonization in policies to minimize HIV transmission and support informed feeding choices.
Article Synopsis
- The study looked at how serious Human Adenovirus (HAdV) infections are compared to other viral illnesses in kids with breathing problems in Italy.
- They found that kids with HAdV showed more inflammation but didn't have worse breathing issues than those with other viruses.
- The research highlights the need to identify HAdV early to avoid giving unnecessary antibiotics, since many kids might get treated for bacterial infections when they really have a virus.
Article Synopsis
- Parvovirus B19 (PVB19) is a small virus that often causes mild or no symptoms, but in children, it can lead to various conditions like rashes and joint pain.
- Three pediatric cases from Milan in March 2024 showed different manifestations of PVB19, including rashes and low platelet counts.
- The findings stress the virus’s potential complications, highlight the need for careful diagnosis during outbreaks, and point out the importance of understanding PVB19's epidemiological patterns for better management in children.