Publications by authors named "V Giacomarra"
Article Synopsis
- Head and Neck Squamous Cell Cancer (HNSCC) is a significant health concern, ranking sixth among global cancers, with a pressing need for new therapies and biomarkers due to slow advancements in treatment personalization.!* -
- This study analyzed the somatic mutations in 15 specific genes related to HNSCC in a high-incidence area of Italy, finding unique mutation patterns that may have prognostic implications, particularly in the hypopharyngeal region.!* -
- The research revealed that while certain mutations indicate poorer prognosis, they currently lack sufficient evidence to be used as predictive biomarkers, highlighting the necessity for further studies to improve treatment options for HNSCC patients.!*
Background: Tonsillectomy and adenotonsillectomy are surgical procedures routinely performed worldwide, with various complications, including postoperative bleeding (PTH). Among haemostatic agents, bismuth subgallate (BS) has been employed in the past decades, but its use is controversial in children.
Objective: This retrospective, multicentre study aims to evaluate the effectiveness and safety of BS in preventing PTH following tonsillectomy and adenotonsillectomy.
Blood Markers Predicting Clinically Occult Lymph Node Metastasis in Head and Neck Squamous Cell Carcinoma.
ORL J Otorhinolaryngol Relat Spec
February 2024
Introduction: The presence of cervical lymph node metastases is an unfavorable prognostic factor in head and neck squamous cell carcinoma (HNSCC) and a potential cause of treatment failure. Occult lymph node metastasis occurs in approximately 15-20% of HNSCC patients with a clinically negative neck (cN0), greatly impacting on their prognosis. The present study aimed to investigate the role of pre-treatment peripheral blood markers in predicting clinically occult cervical lymph node metastasis.
View Article and Find Full Text PDFObjectives: To evaluate the prognostic value of pre-treatment prognostic-nutritional index (PNI) in patients with HPV-negative head and neck squamous cell carcinoma (HNSCC).
Methods: A multi-institutional retrospective series of HPV-negative, Stages II-IVB, HNSCCs treated with upfront surgery was evaluated. Correlation of pre-operative blood markers and PNI with 5-year overall (OS) and relapse-free (RFS) survival was tested using linear and restricted cubic spline models, as appropriate.
Rising Trend in the Prevalence of HPV-Driven Oropharyngeal Squamous Cell Carcinoma during 2000-2022 in Northeastern Italy: Implication for Using p16 as a Surrogate Marker for HPV-Driven Carcinogenesis.
Cancers (Basel)
May 2023
Article Synopsis
- The study explores the rising rates of oropharyngeal squamous cell carcinomas (OPSCCs) associated with HPV infections in Northeastern Italy, revealing an increase from 12% to 50% in HPV-driven cases between 2000-2022.
- A total of 390 patients were included, with findings showing that HPV-driven OPSCCs are more prevalent in the tonsils and base of the tongue, reaching 59%, compared to less than 10% in other areas.
- The research highlights the need for institutions to consider specific prevalence rates when using p16 overexpression as a marker for HPV-driven cancers, as this significantly influences its predictive value.