Advancing energetic chemistry: the first synthesis of sulfur-based C-C bonded thiadiazole-pyrazine compounds with a nitrimino moiety.

Sulfur-based energetic materials 3 to 7 were synthesized considering the limited availability of structural combinations of polynitrogen- and oxygen-based organic scaffolds, thereby advancing their limits. All of them were fully characterised using infrared spectroscopy (IR), multinuclear magnetic resonance spectroscopy (NMR), high-resolution mass spectrometry (HRMS), elemental analysis (EA), and differential scanning calorimetry (DSC) studies. Furthermore, the molecular structure of compound 3 was confirmed using single-crystal X-ray diffraction studies (SC-XRD).

Skeletal Editing of Energetic Materials: Acid-Catalyzed One-Step Synthesis of Bridged Triazoles as High-Energy-Density Materials via the Nef Reaction.

Thermally stable insensitive energetic materials have captivated significant attention from the global research community due to their potential impact. In this study, a series of symmetric and asymmetric nitromethyl-bridged triazole compounds were synthesized from pyrimidine moieties via a skeletal editing approach. Additionally, carbonyl-bridged compounds were synthesized in a single step by using acid-catalyzed Nef reactions from their nitromethyl precursors.

Synthesis and Performance Evaluation of Zwitterionic C-N Bonded Triazole-Tetrazole-Based Primary Explosives.

Developing advanced metal-free nitrogen-enriched primary explosives is challenging due to the inherent risks associated with their synthesis and handling. However, there is an urgent need to develop novel lead-free, nitrogen-rich primary explosives that offer balanced energetic properties. C-N bonded bicyclic compound 3-azido-1-(1-tetrazol-5-yl)-1-1,2,4-triazol-5-amine (), its salts, and 3,5-diazido-1-1,2,4-triazole () were synthesized from inexpensive starting materials resulting in a fine blend of sensitivity and stability.

Synthesis of C-C bonded trifluoromethyl-based high-energy density materials the ANRORC mechanism.

A trifluoromethyl group substituted C-C bonded nitrogen rich energetic material 3-(3-nitro-1-pyrazol-4-yl)-5-(trifluoromethyl)-1,2,4-oxadiazole (4), its hydroxyl amine (5) and 3,6,7-triamino-7-[1,2,4]triazolo[4,3-][1,2,4]triazol-2-ium (6) salts and hydrazinium 5-(3-nitro-1-pyrazol-4-yl)-3-(trifluoromethyl)-1,2,4-triazol-1-ide (7) were synthesized and fully characterized using infrared spectroscopy (IR), multinuclear magnetic resonance (NMR) spectroscopy (H, C, and F), high-resolution mass spectrometry (HRMS), elemental analysis (EA) and differential scanning calorimetry (DSC) studies. Furthermore, compounds 4 and 7 were confirmed using single-crystal X-ray diffraction studies (SC-XRD). All compounds possess good density (1.

Uterine Artery Embolization: A Case Report on Primary Postpartum Hemorrhage Management.

When traditional therapies fail to control obstetric emergencies such as postpartum hemorrhage (PPH), uterine artery embolization (UAE) has become an essential intervention. This case study demonstrates the effective use of UAE in a 32-year-old patient who had an elective cesarean section and was experiencing refractory PPH. Despite initial attempts at controlling bleeding with uterotonic agents and surgical intervention, the hemorrhage persisted, necessitating packed red blood cell transfusion.