Publications by authors named "V Garzero"
Article Synopsis
- When BRCA1 and BRCA2 genes are mutated, they can't fix DNA breaks properly, which can lead to cancer.
- Scientists found that cells with BRCA1 mutations rely on a factor called EXO1 to fix DNA damage, making EXO1 a weak spot for these cells.
- If EXO1 is missing in BRCA1-mutated cells, they struggle to repair DNA breaks, but BRCA2-mutated cells can still manage without EXO1, suggesting that targeting EXO1 could help treat BRCA1-related cancers.
Deficiency for the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR) leads to chromosomal instability and diseases such as cancer. Yet, defective HR also results in vulnerabilities that can be exploited for targeted therapy. Here, we identify such a vulnerability and show that BRCA1-deficient cells are dependent on the long-range end-resection factor EXO1 for survival.
View Article and Find Full Text PDFAims/hypothesis: The blood triacylglycerol level is one of the main determinants of blood Mg concentration in individuals with type 2 diabetes. Hypomagnesaemia (blood Mg concentration <0.7 mmol/l) has serious consequences as it increases the risk of developing type 2 diabetes and accelerates progression of the disease.
View Article and Find Full Text PDFMapping proteins at a specific subcellular location is essential to gaining detailed insight on local protein dynamics. We have developed an enzymatic strategy to label proteins on a subcellular level using arylamine N-acetyltransferase (NAT). The NAT enzyme activates an arylhydroxamic acid functionality into a nitrenium ion that reacts fast, covalently, and under neutral conditions with nucleophilic residues of neighboring proteins.
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