Publications by authors named "V Garimella"
Failure of central nervous system (CNS) axons to regenerate after injury results in permanent disability. Several molecular neuro-protective and neuro-regenerative strategies have been proposed as potential treatments but do not provide the directional cues needed to direct target-specific axon regeneration. Here, we demonstrate that applying an external guidance cue in the form of electric field stimulation to adult rats after optic nerve crush injury was effective at directing long-distance, target-specific retinal ganglion cell (RGC) axon regeneration to native targets in the diencephalon.
View Article and Find Full Text PDFBackground And Aims: Early identification of malignant biliary strictures (MBSs) is challenging, with up to 20% classified as indeterminants after preliminary testing and tissue sampling with endoscopic retrograde cholangiopancreatography. We aimed to evaluate the use of methylated DNA markers (MDMs) from biliary brushings to enhance MBS detection in a prospective cohort.
Approach: Candidate MDMs were evaluated for their utility in MBS diagnosis through a series of discovery and validation phases.
Pyoderma gangrenosum (PG) is a neutrophilic dermatosis characterized by ulcerative painful lesions with violaceous undermined borders. Up to 75% of PG cases develop in association with an underlying systemic disease. Monoclonal gammopathy is reportedly a concomitant condition with PG, with studies indicating immunoglobulin (Ig) A gammopathy as the most common.
View Article and Find Full Text PDFBackground And Aims: Endoscopic ultrasound shear wave elastography (EUS-SWE) is a novel modality for liver stiffness measurement. The aims of this study are to evaluate the performance and reliability of EUS-SWE for detecting advanced liver disease in a prospective cohort.
Methods: EUS-SWE measurements were prospectively obtained from patients undergoing EUS between August 2020 and March 2023.
Article Synopsis
- * The symptoms of angiosarcoma can vary widely, presenting as anything from bleeding spots to larger masses, which may eventually lead to serious complications like ulceration.
- * Treatment requires a comprehensive approach involving surgery, radiation, and chemotherapy, and there is currently limited research on lower limb cases, prompting the need for healthcare providers to consider angiosarcoma in patients with lymphedema-related symptoms.