Publications by authors named "V Gailus-Durner"
Article Synopsis
- The lncRNA Crossfirre is an X-linked gene that is transcribed opposite to another lncRNA called Firre, and together with Dxz4, they form significant chromatin structures specific to inactive X chromosomes.
- Researchers carried out large-scale knockout studies of Crossfirre, Firre, and Dxz4 to understand their in vivo roles, finding that although these loci have unique epigenetic traits, they are not crucial for X chromosome inactivation processes.
- The study reveals that Crossfirre influences the regulation of autosomal genes, but only in conjunction with Firre, and includes a phenotyping analysis that highlights various knockout and sex-specific outcomes.
Article Synopsis
- Scientists are studying how to help the body make more insulin-producing β-cells to manage diabetes better.
- They used zebrafish to see if liver cells (hepatocytes) can help regenerate these β-cells but found they don’t turn into β-cells themselves.
- A special process involving something called molybdenum cofactor may be important for both making β-cells and managing sugar levels in the body, which could help in understanding diabetes better.
Article Synopsis
- Mitochondrial fusion and fission are vital for stress responses and managing metabolic changes, which involves the protein Opa1 in its various forms.
- The study involved creating mouse models with specific Opa1 isoforms to determine their role, showing that both cleavable and non-cleavable forms support embryo and adult mouse health.
- Opa1 processing isn't essential for dealing with metabolic or thermal stress but is crucial for longevity and heart health in mice with faulty energy production, indicating its importance in regulating heart growth and metabolism.
Thyroid hormone (TH) effects are mediated through TH receptors (TRs), TRα1, TRβ1, and TRβ2. The TRs bind to the DNA and regulate expression of TH target genes (canonical signaling). In addition, they mediate activation of signaling pathways (noncanonical signaling).
View Article and Find Full Text PDFSpermatozoa harbour a complex and environment-sensitive pool of small non-coding RNAs (sncRNAs), which influences offspring development and adult phenotypes. Whether spermatozoa in the epididymis are directly susceptible to environmental cues is not fully understood. Here we used two distinct paradigms of preconception acute high-fat diet to dissect epididymal versus testicular contributions to the sperm sncRNA pool and offspring health.
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