Publications by authors named "V Gaia"
Currently there is no detailed, internationally agreed protocol defined to evaluate antimicrobial susceptibility testing (AST) for Legionella pneumophila (required to establish epidemiological cut-off value or "ECOFF" boundaries); therefore, antimicrobial resistance in these isolates cannot be defined. AST methods utilising media containing activated charcoal as an ingredient, to enable Legionella growth, are unreliable as noted in an internationally authored opinion paper and a new gold standard is required. Here we define a detailed protocol for broth microdilution (BMD) using defined cell culture collection-deposited control reference strains (Philadelphia-1 and Knoxville-1) as well as two accessible reference strains with moderately (lpeAB-carrying) and markedly (23S rRNA mutation-carrying) elevated azithromycin minimum inhibitory concentration (MIC).
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- - This study investigated how bloodstream infections (BSI) affect patients with cardiac implantable electronic devices (CIED), focusing on those with implantable cardioverter defibrillators (ICD) and cardiac resynchronization therapy devices (CRT-D) treated in a single hospital over several years.
- - Out of 515 patients studied, 36 experienced 47 episodes of BSI, mainly in non-cardiology units, and most did not receive necessary cardiac imaging, emphasizing a gap in diagnosis and treatment.
- - BSI patients had a significantly higher risk of all-cause mortality (6.7 times higher), suggesting that inadequate assessments are leading to missed diagnoses of complications like lead-related endocarditis, pointing to the
Switzerland has one of the highest annual Legionnaires' disease (LD) notification rates in Europe (7.8 cases/100,000 population in 2021). The main sources of infection and the cause for this high rate remain largely unknown.
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