APPROACHES TO PHARMACOLOGICAL CORRECTION OF PSYCHOPHYSIOLOGICAL STRESS IN ATHLETES.

The aim of the study was to assess the effectiveness of the influence of the medical drug tivortin®aspartate (drinking solution of L-arginine aspartate) on the psychophysiological characteristics and the severity of psychophysiological stress in qualified athletes at the stage of direct preparation for the competition. Methodologically, the studies, which are randomized, blind, placebo-controlled, during the course (14 days) of drug usage in a daily dose of 40 ml were carried out in compliance with bioethical principles. The athletes in the control subgroups received placebo (3% glucose solution) in identical dosage, multiplicity and duration of usage.

[The change of objective parameters of voice after laryngeal reinnervation].

Possibilities and late results of nonselective surgical reinnervation, using formation of primary or deferred anastomosis of n. laryngeal recurrence (NLR) with one of cervical peripheral nerves (proximal fragment of NLR, the main branch of cervical loop - ansa cervicalis, nerve-donor) in a one-sided laryngeal paralysis, were studied up. Preoperatively and postoperatively the indirect laryngoscopy, videolaryngoscopy, the voice spectral analysis (main frequency, intensity and the rate harmonics-noise RHN, maximal period of phonation--MPP) were accomplished, subjective selfestimation by a patient of the voice quality (VHI-30) was done.

[The activity of interferon-dependent 2',5'-oligoadenylatesynthetase in rat thymus lymphoid cells under the action of ethanol and acetic zinc administration].

The activity of interferon-induced 2',5'-oligoadenylatesynthetase (2',5'-OA-synthetase) in thymocytes of rats simultaneously treated with ethanol and acetic zinc preparation was studied. The 2',5'-OA-synthetase activity was decreased by 75% after daily ethanol administration for 14 days. The changes were less pronounced at the late terms of the experiment.

[Development of a prediabetic state under chronic alcohol intoxication].

We investigated the changes in key parameters of carbohydrate and lipid metabolism, which correspond to the clinical picture that accompanies the development of prediabetic condition on the background of chronic alcohol intoxication. From the analysis of glycemic curves obtained during the insulin-glucose test, a speed of glucose uptake by peripheral tissues increased at the 1st day (1.5 fold) and the third day (1.

[Epigenetic epidemiology of age-related diseases].

Many studies have shown that our organism is mostly sensitive to different influences in pre- and postnatal periods of ontogenesis. During the critical periods of maturation, these influences induce changes in the organism that relate to ontogenetic plasticity and lead to permanent changes in structure and function of different organ systems of the organism. It is suggested that the main molecular mechanisms of so-called "ontogenetic programming" are based on changes that occur on the epigenetic level, including changes in the genetic expression not connected with modifications of DNA structure.