Radiats Biol Radioecol
August 1998
In the present work, fast repair after combined irradiation by fast electrons and alpha particles was studied in diploid yeast cells Saccharomyces cerevisiae of wild-type XS 800 and its radiosensitive mutant XS 1898. It was shown, that the fast repair significantly contribute to detected survival of the wild-type cells, while this repair is absent in XS 1898 mutant cells. An efficiency of the fast repair under combined irradiation (electrons + alpha particles), assessed on DMF of alpha particles, is lower, than that under irradiation by electrons and alpha particles separately.
View Article and Find Full Text PDFEffects of simultaneous irradiation of diploid yeast cells with various genotypes with alpha-particles, gamma-rays or fast electrons were studied. When contribution of sparsely ionizing radiation to the overall dose is small (up to 25%) antagonism was observed, while at the 95% contribution there seems to be a tendency towards synergistic effect; at 50% contribution the results of the simultaneous combined irradiation do not contradict hypothesis on independent effect of radiation with different LET, which also implies a change in the RBE of simultaneous irradiation.
View Article and Find Full Text PDFRadiats Biol Radioecol
September 1994
Fast repair in diploid yeast cells Saccharomyces cerevisiae XS800 exposed to the combined irradiation (alpha-particles + high-velocity electrons) was studied. It has been shown that fast repair was significantly more effective after combined irradiation with high doses than after exposure to high-velocity electrons or alpha-particles alone. The regions of radioresistance in the cell survival curves after combined irradiation can be explained by fast post-irradiation repair.
View Article and Find Full Text PDFA mode of formation of wide fields of fast electrons at LUE-25 accelerator is proposed to expose uniformly the extended 4 cm thick biological objects. Dosimetric characteristics of the electron beams have been studied by film and ferrous-sulfate dosimeters. The potencies and limitations of using the dosimeters as a "witness" are discussed.
View Article and Find Full Text PDFIn order to study the early biological effects of whole-body and partial exposure of biological objects to high doses of fast electrons a simple and reliable method has been developed for the purposes of the control and correction of the dose-rates. The measurements were made of spatial distribution, in air and water, of the doses used for irradiation of the laboratory animals and cell suspensions with the indicated nonuniformity coefficients.
View Article and Find Full Text PDF