[Diagnostic value of urinary biomarkers excretion in estimation of morphological lesions in patients with primary glomerulopathies].

Aim: To investigate the diagnostic value of biomarkers in assessing the severity of sclerotic and atrophic lesions in primary glomerulopathies.

Materials And Methods: One hundred patients were included in the study, according to the results of kidney biopsy in 9 (9%) cases minimal change disease was diagnosed, in 28 (28%) focal segmental glomerulosclerosis, in 26 (26%) membranous nephropathy and in 37 (37%) IgA nephropathy. The clinical course of nephropathy was evaluated, standard laboratory tests were performed, and urinary excretions of cystatin C, 1-microglobulin, 2-microglobulin and NGAL were measured.

[A case of diagnosing lipoprotein glomerulopathy in Russia].

Lipoprotein glomerulopathy (LPG) is a rare disease characterized by specific histological, immunomorphological, and ultrastructural changes. The main pathomorphological signs of LPG are lipoprotein thrombi in the lumen of the capillary loops, proteinuria, and dyslipoproteinemia as an increased concentration of apolipoprotein E (phenotypes E2/E3, E2/E4). A patient aged 47 years had nephrotic syndrome with a daily protein loss of 12.

[Diagnostic value of cystatin C and neutrophil gelatinase-associated lipocalin in primary glomerulopathies].

Aim: To study an association between clinical and morphological evidence and the serum and daily urinary levels of cystatin C (CysC) and neutrophil gelatinase-associated lipocalin (NGAL) in patients with primary glomerulopathies.

Subjects And Methods: The investigation included 104 patients; morphological examination showed minimal change disease in 15 (14.4%) patients, focal segmental glomerulosclerosis in 24 (23.

[Anti-glomerular basement membrane glomerulonephritis concurrent with membranous nephropathy].

The paper describes a case of anti-glomerular basement membrane glomerulonephritis (anti-GBM GN) concurrent with membranous glomerulopathy (MGP) in a 25-year-old female patient. The diagnosis was established on the basis of clinical, laboratory, and pathomorphological data, including electron microscopic ones). The comprehensive analysis, including ultrastructural diagnosis, is shown to be important in identifying this rare combination of two nosological entities, anti-GBM GN and MGP, in the same patient.

[Plasma membrane focal defects in structurally normal cells].

The technique of perfusion fixation through the rat kidney vasculature was modified to ensure the highest possible level of cell preservation close to that under in vivo conditions. Electron microscopic analysis of the tissue specimens treated in such a way revealed local defects of the plasma membrane in a number of cells than that otherwise looked normal. These findings together with the evidence for reparability of such defects and some data on the purely artificial nature of certain alterations should be taken into consideration in order to avoid misinterpretations while diagnosing the biopsy specimens.