Publications by authors named "V G Sameera Sampath"
Bronchopulmonary dysplasia, the most prevalent chronic lung disease of prematurity, is often treated with glucocorticoids (GCs) such as dexamethasone (DEX), but their use is encumbered with several adverse somatic, metabolic, and neurologic effects. We previously reported that systemic delivery of the GC prodrug ciclesonide (CIC) in neonatal rats activated glucocorticoid receptor (GR) transcriptional responses in lung but did not trigger multiple adverse effects caused by DEX. To determine whether limited systemic metabolism of CIC was solely responsible for its enhanced safety profile, we treated neonatal rats with its active metabolite desisobutyryl-ciclesonide (Des-CIC).
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- The review covers the genetic and epigenetic factors related to food allergies, including their inheritance and the advantages and limitations of study methods.
- Genome-wide association studies have identified 16 significant genetic variants linked to food allergies, often overlapping with other allergic conditions.
- The article emphasizes the importance of integrating genetic and epigenetic data for understanding disease mechanisms and suggests future implications for predicting food allergy risks and responses to treatment.
Burning of fossil fuels along with deforestation and ecological disruption have led to the warming of the Earth and climate change. Children are especially vulnerable to adverse health effects of climate change associated changes in the air, soil, and water as their organs are still developing, have a faster breathing rate, higher per pound ingested and inhaled exposures, and greater relative body surface area. To protect this vulnerable population, health care professionals need to play a leading role.
View Article and Find Full Text PDFBackground: Pathogenic Escherichia coli strains produce neonatal septicemia after colonizing the neonatal gut. While the probiotic Lactobacillus rhamnosus GG (LGG) effectively reduces neonatal sepsis, LGG's effects on the neonatal intestinal microbiota alterations and inflammation triggered by E. coli are incompletely understood.
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- - Epigenetic modifications play a crucial role in regulating gene expression, allowing cells to turn genes on and off, which is essential for maintaining different cell types.
- - Environmental factors like diet and pollutants can alter these epigenetic modifications, meaning that an individual's surroundings can impact gene expression and health outcomes, potentially even affecting future generations.
- - The review discusses how epigenetic changes can be passed down through generations, examines the mechanisms behind these changes, and emphasizes the importance of considering environmental health for both current and future populations.