Publications by authors named "V G Nikolaev"
A quantitative assessment of wound status in a murine model was developed using phasor plot presentation of fluorescence lifetime imaging microscopy (FLIM) data. The quantitative assessment is based on calculating Bhattacharyya distance between g coordinates of FLIM data phasor plot density distributions of wound and healthy skin. The approach was validated for both diabetic and non-diabetic mice wounds, including during low-dose photodynamic therapy (LDPDT).
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- * Various diagnostic methods exist to detect TB biomarkers like DNA, proteins, and antibodies using techniques such as PCR, ELISA, and flow cytometry, which help identify infections through optical signals.
- * Recent advancements in biosensing focus on enhancing detection sensitivity using fluorescent quantum dots, which offer brighter and more stable optical tags for identifying TB biomarkers more effectively.
Stroke is the main cause of disability among adults. Decision-making in stroke rehabilitation is increasingly complex; therefore, the use of decision support systems by healthcare providers is becoming a necessity. However, there is a significant lack of software for the management of post-stroke telerehabilitation (TR).
View Article and Find Full Text PDFSulfonylureas (SUs) are a class of antidiabetic drugs widely used in the management of diabetes mellitus type 2. They promote insulin secretion by inhibiting the ATP-sensitive potassium channel in pancreatic β-cells. Recently, the exchange protein directly activated by cAMP (Epac) was identified as a new class of target proteins of SUs that might contribute to their antidiabetic effect, through the activation of the Ras-like guanosine triphosphatase Rap1, which has been controversially discussed.
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- The study investigates the role of Na+-activated Slack potassium channels in regulating neuronal and cardiovascular activity, particularly during ischemia and reperfusion (I/R) injury.
- Researchers found that Slack channels are essential for K+ currents in cardiomyocytes and help prevent excessive Ca2+ accumulation, which can lead to cell death under low oxygen conditions.
- The findings emphasize Slack's critical role in maintaining ion balance in heart cells, suggesting that its activity may protect against cardiac damage during I/R injuries.