[Antimutagenic properties of substances containing beta-carotene].

Two carotene-containing drugs (natural and artificial) were shown to decrease the rate of chromosomal aberrations, induced by cyclophosphane, in bone marrow cells of mice, daily ration of which contained 10-20 mg/kg of beta-carotene within 1-3 weeks. The rate of chromosomal aberrations induced was decreased 1.5-2-fold in various experiments.

[The effect of lipochromin on spontaneous carcinogenesis in mice].

Development of spontaneous hepatomas was studied in CBA mice, which were maintained on a diet containing the carotenoid drug lipochromine in a dose of 25 mg/kg during their life beginning at the age of 3 months twice a week. Concentrations of vitamin A (as retinol) and beta-carotene were estimated in mice blood and liver tissue by means of HPLC. Decrease in occurrence of spontaneous tumors in liver tissue as well as distinct increase in periods of their development were detected in the animals treated with the drug.