[Osteogenic sarcoma in children: clinico-immunological correlations].

Initial immunologic status in children suffering osteogenic sarcoma was retrospectively evaluated versus such parameters as site and extent of tumor, and clinical course. A complex of disorders in the immunologic system was established in osteogenic sarcoma patients. Such characteristics as levels of active, theophylline--sensitive and levamisole--reactivated T-cells were found clinically valuable and prognostically significant.

[Pharmacokinetics of the antineoplastic agent 14C-prospidin in rats according to distribution data of the radioactive label].

Prospidin--N,N3-di(beta-chloroethyl)-N1,N2-dispirotripiperazinium - is a broad-spectrum antineoplastic drug with low toxicity. Experiments on albino rats with transplanted sarcoma M-1 were made to study the distribution and kinetics of 14C-prospidin labeled in the dispirotripiperazinium part of the molecule. On being given intravenously the drug accumulated for 15 minutes.

[Kinetics of accumulation and elimination of 14C-dipine, an antineoplastic drug].

An investigation on evaluating the distribution of 14C-dipine in rats with sarcoma 45 was carried out. With intragastric administration of the drug its resorption occurs largely in the small intestine. The maximally absorbed portion of the tag is detected in 1 hour and by this time it reaches 36.