Enterosorption as a method to decrease the systemic toxicity of cisplatin.

Unlabelled: A perspective adsorptive method to minimize systemic toxic effects of chemotherapy is enterosorption (ES). However, the capabilities of this method are far from being completely studied. The question remains opened - should ES be initiated in the first hours on completing cytostatic infusion without the risk of their anticancer activity to be decreased.

The study of possibility to elevate antitumor activity and decrease of systemic toxic effects of cisplatin by its binding with deliganded albumin.

Aim: To evaluate antitumor and toxic action of cisplatin (CP) in non-bound form and in a complex with deliganded albumin.

Methods: To study complex-formation between CP and albumin, differential scanning and isothermic flow microcalorimetry were used. For quantitive evaluation of albumin-bound CP, the method of ultrafiltration was applied.

[Automation in research of occupational morbidity among transport workers].

Universal PC software served as a based for automated system collecting information on morbidity among transport workers and proposing models and statistic analysis. The system was tested in following PC: ISKRA 1030, EC 1840, IBM PC/XT, IBM PC/AT. Automatic analysis of morbidity among sailors used a new medical and statistic parameter called "probability of accumulated morbidity".

[Concentration of circulating immune complexes in the blood in clinical and experimental epileptic seizures].

The levels of circulating immune complexes (CIC) in the peripheral blood were studied in 31 epileptic patients and 30 rabbits which served as an experimental model of the development of the epileptic process. CIC levels in the blood serum were measured by means of polyethylene glycol precipitation followed by measurement of optic density by a spectrophotometer. Elevated concentrations of CIC in the patients' blood were observed in the period of the epileptic status and during a series of epileptic attacks, as well as in experimental animal during epileptic attacks and in the period preceding their development.