Branched Amphiphilic Polylactides as a Polymer Matrix Component for Biodegradable Implants.

The combination of biocompatibility, biodegradability, and high mechanical strength has provided a steady growth in interest in the synthesis and application of lactic acid-based polyesters for the creation of implants. On the other hand, the hydrophobicity of polylactide limits the possibilities of its use in biomedical fields. The ring-opening polymerization of L-lactide, catalyzed by tin (II) 2-ethylhexanoate in the presence of 2,2-bis(hydroxymethyl)propionic acid, and an ester of polyethylene glycol monomethyl ester and 2,2-bis(hydroxymethyl)propionic acid accompanied by the introduction of a pool of hydrophilic groups, that reduce the contact angle, were considered.

Biodegradable and Biocompatible Silatrane Polymers.

In this study, new biodegradable and biocompatible amphiphilic polymers were obtained by modifying the peripheral hydroxyl groups of branched polyethers and polyesters with organosilicon substituents. The structures of the synthesized polymers were confirmed by NMR and GPC. Organosilicon moieties of the polymers were formed by silatranes and trimethylsilyl blocks and displayed hydrophilic and hydrophobic properties, respectively.

[Clinical and biochemical aspects of pathogenesis of urolithiasis].

Aim: To investigate the role of infection in the pathogenesis of urolithiasis using chromatography mass spectrometry analysis.

Materials And Methods: The study analyzed clinical and laboratory data of 316 urolithiasis patients hospitalized between February 2005 and January 2015. All patients underwent a comprehensive clinical examination, including laboratory tests (hematological and biochemical blood tests, clinical and bacteriological tests of urine) and chromatography mass spectrometry analysis urine and blood.

[The clinical laboratory evaluation of impact of shock wave on the activity of peptidohydrolase in urine of patients with urolithiasis].

The article presents the results of comprehensive clinical biochemical study of 79 patients with urolithiasis admitted to the urologic department of public clinical hospital No 7 in 2007-2009. The diagnostic evaluation of the impact of shock wave on kidney parenchyma and crystallization processes was implemented. The chromatography-mass spectrometry was applied to analyze the activity of hydrolytic enzymes in urine of patients with urolithiasis underwent the remote lithotripsy sessions.

[Role of an infectious factor in the pathogenesis of urolithiasis].

The paper gives the data of complex clinical and biochemical examination in 122 urolithiasis (ULT) inpatients treated at the Urology Unit, Moscow City Clinical Hospital Seven, in February 2004 to January 2008. The levels of lithogenic substances and compounds, inhibitors and activators of lithogenesis have been determined. The authors show it possible to use the level of hydrolytic enzymes and activators of cooperative microbial sensitivity as diagnostic and prognostic criteria in diferent forms of ULT, which is in turn of no small importance in developing the science-based methods for the treatment and prevention of recurrent lithogenesis.