[Effect of diuretics on vascular permeability and proliferative inflammation in rats].

It is shown that ethacrynic acid and dichlothiazide in 50 mg/kg dose reduce the dextran-induced increase of rat skin vascular permeability. Besides, durable administration of furosemide, dichlothiazide and ethacrynic acid in 50-80 mg/kg doses decreases the dry mass of inflammatory granuloma. This fact shows the ability of diuretics to suppress the development of proliferative inflammation.

[Effect of diuretics on the development of experimental inflammatory edema in rats].

Experiments on rats have shown that administration of furosemide, dichlothiazide and etacrinic acid (50 mg/kg intraperitoneally) reduced the development of experimental inflammatory edema caused by subplantar administration of 0.1 ml of 6% dextran or 10% ovalbumin. The antiedematous effect of the diuretics was preserved under the conditions of bilateral nephrectomy, which points to the presence of extrarenal mechanisms in the action of the drugs in experimental inflammation.