Prehistoric and technogenic loads of Hg in raised and blanket peats from the lower Amur River basin, eastern Asia.

Prehistoric and modern records of Hg in peats from the lower Amur River basin, eastern Asia, were investigated. The Hg accumulation rates (AR) of two C-dated cores from Holocene raised and blanket peats were determined. The low and monotonous Hg AR values of the raised peats determined in the lower part of the core (mean 1.

[Neuroprotective effects of succinate-containing antihypoxante reamberine in treatment of patients with toxicohypoxic brain injury].

As a result of survey in process of treatment of 60 patients with severe acute poisoning complicated by the toxic-hypoxic brain edema, found that inclusion of reamberin (antihypoxant containing succinate) in basic therapy leads to increase levels of the antioxidant defense system, decrease lipid peroxidation and reduce NR2A titers of autoantibodies. Reduction of degree of toxic-hypoxic encephalopathy promotes improving the clinical course, manifested shortened duration of coma and hospital bad days.

[Mechanism of neuroprotector action of metabolic antihypoxant reamberin in patients with toxicohypoxic encephalopathy].

Based on investigation of a group of patients with heavy forms of sharp poisoning by neurotropic substances, it is established that inclusion if antihypoxant reamberin in intensive treatment of toxicohypoxic encephalopathy leads to a decrease in the depth of central nervous system depression. This is manifested by reduced duration of patient stay in coma and decreased total duration of resuscitation treatment. Improvement of the clinical picture is accompanied by a decrease in lipid peroxidation activity, increase in the level of antioxidant enzymes, and decrease in the level of NR2A auto-antibodies.

[Method of pharmacological treatment of the consequences of hypoxia in critically ill patients with acute poisoning].

The multi-factor effect of pharmacological preparations reamberine and citotoflavine, which contain succinate, in critical conditions is preconditioned by the impact they produce on a total energy deficit caused by a long-term hypoxia. The correction of energy deficit improves the therapy of patients in coma, which resulted from poisonings by neurotropic substances. The therapeutic effect manifested itself through a shorter state of coma from 25 to 12.

[Levels of autoantibodies to glutamate receptors and immunological blood parameters in patients with epilepsy].

The role of glutamate receptors in the brain spiking activity was evaluated. The electroencephalographic (EEG) spiking activity was monitored and autoreactive antibodies (aAbs) to subunits of glutamate receptors were assessed in the blood serum of epileptic and ischemic stroke patients. We showed that the level of GluR autoantibodies in blood serum of patients correlates to the intensity of the brain paroxysmal activity.