Publications by authors named "V G Bairov"
Background: Congenital hyperinsulinism (CHI) is a rare life-threatening disease characterised by persistent hypoglycaemia as a result of inappropriate insulin secretion, which can lead to irreversible neurological defects in infants.
Aim: To evaluate neurophysiological characteristics of central nervous system in children with congenital hyperinsulinism treated according to the international protocol in Russian Federation.
Materials And Methods: Our retrospective, prospective cohort study included 73 patients who received treatment for CHI according to the current international protocol at different departments of the Almazov National Medical Research Centre from 2017 to 2022.
Clostridioides difficile infection (CDI) has become a serious medical and epidemiological problem with a marked increase in incidence and severity [1]. CDI is responsible for 15-25% of all anti-biotic-associated diarrhea cases, with a considerable increase in the 21st century [2]. Recommended first-line therapy for CDI involves oral vancomycin [1].
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- Congenital hyperinsulinism (CHI) exists in three forms: diffuse (CHI-D), focal (CHI-F), and atypical (CHI-A), with surgical treatment relying on preoperative imaging and intraoperative diagnosis.
- The study involved 35 CHI patients and analyzed PET/CT data, cytological, and immunohistochemical features of pancreatic samples, revealing significant differences in cell types and protein expressions among the CHI forms compared to a control group.
- The findings suggest that quantitative cytological and immunohistochemical analysis can aid in the intraoperative diagnosis of CHI forms, highlighting the potential for developing targeted therapy using a NeuroD1 inhibitor.
Mesenterial hypoperfusion is one of the main pathogenetic factors of necrotizing enterocolitis (NEC) in infants with ductus-dependent congenital heart diseases. NEC in infants undergoing congenital heart surgery increases mortality and length of hospital stay. NEC is also associated with adverse neurodevelopmental outcome.
View Article and Find Full Text PDF[Clinical, genetic, and radionuclide characteristics of the focal form of congenital hyperinsulinism].
Probl Endokrinol (Mosk)
November 2019
Background: Congenital hyperinsulinism (CHI) is a severe disease with a high risk of complications including neurological deficit. Persistent hypoglycemia in patients with focal form of CHI can not be managed with medical treatment in 96.4% of cases, what subsequently leads to surgical treatment.
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