Promising approaches in the extraction, characterization, and biotechnological applications of ursolic acid: a review.

Ursolic acid (UA), a pentacyclic triterpenoid, has gained attention for its pharmacological properties and industrial uses. This study explores natural sources of UA, including , apple peels, sage, rosemary, and holy basil, while emphasizing sustainable extraction methods. Advanced techniques like Soxhlet extraction, solvent extraction, supercritical fluid extraction (SFE), enzyme-assisted extraction (EAE), microwave-assisted extraction (MAE), and ultrasound-assisted extraction (UAE) are optimized to enhance yield and purity.

Mangiferin as a potential inhibitor of transthyretin fibrillogenesis.

By using in silico molecular docking, we predicted a high potential of mangiferin to inhibit transthyretin amyloidogenesis. Subsequently, we tested this prediction in an in vitro system. The study involved testing effect of mangiferrin in a system that included isolated and purified recombinant transthyretin under fibrillogenesis conditions and a detection assay based on the fluorescent dye thioflavin T, characteristic of amyloid fibrils.

Assessing the Efficacy and Reliability of Pedicled Myocutaneous Single-Staged Flaps in Oral Cancer Ablation Surgery: A Prospective Interventional Study.

Background Reconstructive ladder following cancer ablation surgery varies from the simplest of split skin grafts to the most complex vascularized free tissue transfer flaps. Objectives The study objective is to assess the efficacy and reliability of single-staged pedicled myocutaneous flaps (PMF) for small- and medium-sized cancer defect reconstruction, as well as to evaluate the indications of single-stage PMF in the current free flap era.  Materials and methods This was a prospective interventional study that was conducted over a period of nine months.

Mission Impossible: Densah Bur Revolution in Treating Atrophic Maxilla.

Atrophic maxilla is a condition that compromises the bone density of the jaws. The three-dimensional remodeling of bones makes it more difficult to plan rehabilitation. Bone density plays a key role in implant placement, but in the case of the atrophic maxilla, placement of an implant with conventional burs is difficult and often leads to a failed implant prosthesis.

Role of 2-Deoxy-D-Glucose in Enhancing the Efficacy of Standard of Care for Moderate to Severe COVID-19: A Comparative Analysis of Clinical Outcomes.

Objective This study aimed to evaluate the role of 2-Deoxy-D-Glucose (2-DG) in moderate to severe Coronavirus Disease 2019 (COVID-19) cases. Methodology This study retrospectively analyzed the effects of 2-DG alongside Standard of Care (SOC) for moderate to severe COVID-19 in 150 patients. Eligible patients were aged 18-65, with confirmed COVID-19, who met clinical criteria for moderate or severe illness.