Publications by authors named "V Ford"
Article Synopsis
- Septic shock leads to increased end-diastolic volume (EDV) and decreased ejection fraction in survivors, unlike nonsurvivors, whose EDV does not increase due to more severe diastolic dysfunction early in the condition.* -
- In a study with beagles, findings indicate that septic animals experienced significant heart issues, including wall edema and thinning, resulting in decreased heart performance, particularly in nonsurvivors during the initial phase of sepsis.* -
- The research suggests that cardiac dysfunction during sepsis is connected to microvascular injury and edema, with important implications for understanding heart changes and recovery in septic patients.*
Article Synopsis
- * Beagles were given either saline or epinephrine infusions, with results indicating that while epinephrine significantly increased plasma levels, it did not worsen heart function compared to saline.
- * The findings suggest that heart dysfunction in sepsis is not mainly caused by high levels of catecholamines, but also highlight changes in microcirculatory perfusion and heart function variability between treated and untreated groups.
Article Synopsis
- Septic shock causes significant cardiac dysfunction in both humans and animal models, characterized by increased biventricular end diastolic volume and decreased ejection fraction, with these abnormalities developing over the course of two days and generally reversing by day ten.
- In a study involving purpose-bred beagles, septic animals showed greater left ventricular wall edema and dysfunction compared to controls, with non-survivors displaying more severe changes in cardiac function and size.
- The differential changes in cardiac volume and function between survivors and non-survivors suggest that septic shock impacts heart performance significantly, but the exact mechanisms behind these differences remain unclear.
In this secondary analysis of a multicenter investigation, we describe several gaps in the collection and management of pediatric race, ethnicity, and language data. These findings highlight the ongoing need for reliable data management processes as a crucial step toward advancing pediatric health equity.
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- The study investigates the effectiveness and optimal duration of androgen deprivation therapy (ADT) combined with postoperative radiotherapy for patients with localized prostate cancer following radical prostatectomy.
- A randomised controlled trial, RADICALS-HD, compared short-course ADT (6 months) to long-course ADT (24 months) among participants who met specific criteria, including PSA levels and absence of metastatic disease.
- The primary outcome measured was metastasis-free survival, with the trial aiming to determine if longer ADT duration leads to better survival rates, involving over 1,500 patients from 2008 to 2015.