Biophysical modeling of the whole-cell dynamics of C. elegans motor and interneurons families.

The nematode Caenorhabditis elegans is a widely used model organism for neuroscience. Although its nervous system has been fully reconstructed, the physiological bases of single-neuron functioning are still poorly explored. Recently, many efforts have been dedicated to measuring signals from C.

See Elegans: Simple-to-use, accurate, and automatic 3D detection of neural activity from densely packed neurons.

In the emerging field of whole-brain imaging at single-cell resolution, which represents one of the new frontiers to investigate the link between brain activity and behavior, the nematode Caenorhabditis elegans offers one of the most characterized models for systems neuroscience. Whole-brain recordings consist of 3D time series of volumes that need to be processed to obtain neuronal traces. Current solutions for this task are either computationally demanding or limited to specific acquisition setups.

Collective behavior and self-organization in neural rosette morphogenesis.

Neural rosettes develop from the self-organization of differentiating human pluripotent stem cells. This process mimics the emergence of the embryonic central nervous system primordium, i.e.

Modeling of olfactory transduction in AWC neuron via coupled electrical-calcium dynamics.

Amphid wing "C" (AWC) neurons are among the most important and studied neurons of the nematode In this work, we unify the existing electrical and intracellular calcium dynamics descriptions to obtain a biophysically accurate model of olfactory transduction in AWC neurons. We study the membrane voltage and the intracellular calcium dynamics at different exposure times and odorant concentrations to grasp a complete picture of AWC functioning. Moreover, we investigate the complex cascade of biochemical processes that allow AWC activation upon odor removal.