Insulin resistance and vitamin D deficiency in patients with chronic kidney disease stage 2-3.

Vitamin D status and the relationship between serum 25(OH) vitamin D concentrations and the components of insulin resistance were examined in 120 patients with chronic kidney disease stage 2 and 3. Insulin sensitivity/resistance was calculated by the quantitative insulin sensitivity check index (QUICKI). In this analysis, the prevalence of insulin resistance was 42 %.

Effects of long-term cholecalciferol supplementation on mineral metabolism and calciotropic hormones in chronic kidney disease.

Background: Data on the efficacy and safety of long-term vitamin D supplementation in chronic kidney disease (CKD) are scarce. We assessed the effects of the 12-month vitamin D(3) treatment on mineral metabolism and calciotropic hormones in patients with CKD stages 2-4.

Methods: Eighty-seven patients (mean age 66 years, men/women 33/54) were randomized to cholecalciferol treatment with either 5,000 or 20,000 IU/week.

[Evaluation of the antihypertensive efficacy and tolerability of fixed very low-dose perindopril/indapamid combination in patients with mild to moderate hypertension. Results of a Czech and Slovak multicentric study].

Aim Of The Study: To evaluate the efficacy and tolerability of fixed, low-dose perindopril (2 mg) and indapamide (0.625 mg) combination in patients with mild to moderate hypertension. Secondary aim of the study was to assess the influence of this combination on basic echocardiographic parameters.

[Treatment of postmenopausal osteoporosis with raloxifene].

The authors present the results of the international multicentric clinical study (MORE--The Multiple Outcomes of Raloxifen Evaluation) of postmenopausal osteoporosis by raloxifen, participated by the authors. The evaluation of MORE indicated that raloxifen represents another further significant possibility of the treatment of postmenopausal osteoporosis by increasing bone density of vertebrae and femoral neck, and reducing the risk of vertebral fractures.

[Hypertension in pregnancy].

Hypertensive disorders are the most common medical complications of pregnancy and are an important cause of maternal and perinatal morbidity and mortality. The author presents a review on Hypertension in pregnancy from the point of view of classification, diagnosis and treatment. According to JNC 6 and WHO/ISH recommendations hypertensive disorders of pregnancy can be divided into three categories: 1.