[Tumor necrosis factor as indicator of endogenic intoxication severity in acute neurosensory hypoacusis].

Pathogenesis of acute neurosensory hypoacusis is considered in terms of endogenic intoxication syndrome as impaired microcirculation and development of hypoxia in the periphery of the acoustic analyser are likely consequences of this syndrome. Measurement of tumor necrosis factor alpha level in the supernatant of cultivated mononuclears from patients with acute neurosensory hypoacusis indicated more active production of this mediator compared to donors. This fact justifies further investigations of this disease pathogenesis in respect to disorders in regulation of nonspecific adaptive-compensatory mechanisms.

[Orbital and intracranial complications of paranasal sinus inflammation].

The examination of 2251 patients with paranasal sinusitis has detected various rhinosinusogenic orbital and intracranial complications in 75 of them (3.3% of overall number of sinusitis patients). The complications were caused by acute and chronic paranasal sinusitis in 49 and 26 patients, respectively.

[The use of computed tomography of the temporal bone for the early diagnosis and prognosis of otogenic intracranial complications].

The authors propose three-projection procedure of computed tomography (CT) of the temporal bone aimed at early diagnosis and prognosis of intracranial otogenic complications. CT was conducted in 62 patients with chronic purulent epitympanitis. Destruction of the tympanic bone walls and the antrum, inflammatory involvement of the meninges were seen on CT in 15 patients.

[The diagnosis of campylobacteriosis].

Results of assays for Campylobacter in patients with intestinal dysfunction are presented for the period from 1984 to 1991. 4147 cases were analyzed in 144 of which (3%) Campylobacter was detected in feces. Children constituted 12% of this group.