[Effectiveness of neoadjuvant chemoradiotherapy of locally advanced rectal cancer in conjunction with local hyperthermia and metronidazole].

Our study included 36 patients with hard fixed rectal tumors (T3, T4) who had received combined treatment at the Center's Clinics. On irrigoscopic evidence, lesions were more than 10 cm long. Radiotherapy was conducted thrice a week, STD of 4 Gy--TTD of 40 Gy; capecitabine, per os, 650 mg/m2 twice a day, days 1-22; oxaliplatin, 50 mg/m2, intravenously, days 3, 10 and 17; metronidazole in polymer composition, intrarectally, 10 mg/m2, twice, days 12 and 17 of radiotherapy; local hyperthermia (the <> installation), 460 mHz, 41-45 deg.

[The effect of microwaves on the bioelectric brain activity].

The experiments on rats have shown that the effect of millimeter range electromagnetic radiation on the bioelectric brain activity is dependent on the initial functional state of central nervous system. Microwaves are able to cause a nonspecific electroencephalographic reaction of synchronization and probably the lower the bioelectric brain process dynamics of active rats. Enrichment of electrocorticograms with high-frequency rhythms and increase in degree of bioelectric brain dynamics can be observed in narcosis conditions.

[Definition, classification and combined treatment of locally invasive rectal neoplasms].

From analysis of 490 case records of patients with stage IV A rectal carcinoma, 3 groups of patients were distinguished according to the size of the tumor and the degree of its fixation to the surrounding tissues and growth into the adjacent organs. Such locally spread tumors of the rectum must be subjected to combined treatment: preoperative large-fractional radiotherapy in concurrent local SHF-hyperthermia followed by operation 24-48 hours later. If resectability of the tumor is doubtful, a relieving colostoma is formed in the first stage and distance gammatherapy is applied in a dose of 4 Gy twice a week to a total dose of 32 Gy auring medication with metronidazole and local SHF-therapy.

[Simultaneous resection with the creation of 2 anastomoses in synchronous multiple primary cancer of the large intestine].

The authors analysed surgical treatment of 26 patients with primary multiple carcinoma of the large intestine with localization of synchronous malignant tumors in distal parts of the large intestine. Eight of these patients underwent one-stage resection of the large intestine with the creation of two anastomoses. Establishment of primary anastomoses during one-stage resections for synchronous primary multiple carcinoma of the large intestine with an AKA-2 compression anastomosis apparatus and a "Skalpel-1" laser device did not deteriorate the immediate results of treatment of this group of patients.

[Central mechanisms of thermoregulation and phase transitions of brain lipids pertaining to them].

The experiments in rats and rabbits revealed a correlation among the body temperature, the peripheral temperature threshold, central (thermosensitive neurons) thermoregulatory responses, and the temperature of phasic transition of brain lipids three latter parameters rising during experimental fever. The composition of phospholipids changed in hypothalamic tissues, i.e.