Nucleoli and AgNORs in Hodgkin's disease.

Aim: To evaluate the morphofunctional characteristics of lymph node cells from patients with Hodgkin's disease by measuring silver stained nucleolar organiser regions (AgNORs).

Methods: Nucleoli in Hodgkin's and Reed-Sternberg (HRS) cells, lymphocytes and prolymphocytes were investigated in cytological smears and histological sections of lymph nodes from 32 patients with Hodgkin's disease, and from 34 patients with reactive lymphadenopathy. According to the Rye histological classification of Hodgkin's disease, three cases were the lymphocyte predominant (LP) type, 14 the nodular sclerosing (NS) type, and 15 the mixed cellularity (MC) type.

[The cytogenetic reaction of the lymphocytes to in-vitro irradiation in children born to patients after antitumor radio- and chemotherapy].

Stability of genome of children born to patients after antitumor radio- and chemotherapy was studied. For this aim the peripheral lymphocytes were irradiated in vitro at doses 0, 0.25, 0.

[Comparative evaluation of subtotal irradiation and polychemotherapy in the treatment of patients with lymphogranulomatosis].

Subtotal irradiation after a method developed at the Central Research Roentgeno-Radiological Institute in St.-Petersburg was used as the first stage of antitumor treatment in 15 patients with Hodgkin's disease. In another group of 15 patients with the same disease antitumor treatment was started with a cycle of polychemotherapy.

[Experience in the use of subtotal irradiation at different stages of therapy in lymphogranulomatosis].

A study was made of a possibility to use subtotal irradiation (STI) as an equivalent of chemotherapy for the treatment of 33 Hodgkin's disease patients aged 17 to 77 (of them 25 were treated during the 1st-19th yrs. of therapy, for 8 patients it was the 1st stage of antitumor therapy). ROKUS apparatus and a linear accelerator of 15 MeV were used for irradiation at a single dose of 1.