[Changes in phospholipid components of pulmonary surfactant in experimental influenza infection and their correction by remantadin and deitiforine].

Changes in the levels of total phospholipids and phospholipid fractions of pulmonary surfactant fractions of albino mice intranasally infected with influenza A/Aichi/2/68(H3N2) virus in a dose of 5 LD50 were studied. Reproduction of influenza virus in mice is paralleled by fluctuations in the level of total lipids and changes in the phospholipid components of pulmonary surfactant. Antiviral drugs remantadin and deitiforine injected in accordance with the treatment and prophylaxis protocol to infected animals exerted a protective effect as regards the studied pulmonary surfactant phospholipids.

[The suppression of cellular Na+/H+ exchange leads to the inhibition of influenza virus activity].

It was shown that amiloride, orthovanade and uabain induced almost a two-fold decrease in the rate of incubation medium oxidation by the chick embryo fibroblasts due to the Na+/H+ exchange and inhibited by more than 95 per cent the influenza virus activity. The following mechanism for inhibition of the influenza virus multiplication in the cells under the effect of the above mentioned substances was proposed: suppression of the cellular Na+/H+ exchange responsible for the decrease in pH value in the virus-carrying endosomes----prevention of the decrease in the intraendosomal pH value to the critical level----blocking of the acid dependent process of the virus uncoating----inhibition of the influenza infection as a whole.

[New methods and equipment for studying the hemostatic system (review of the literature)].

The author analyzes the principles and reviews the ranges of application of conductometric, filtration rapid method for studies of formed element aggregation in stabilized blood, hemostographic, photodynamic method for blood clotting registration, superfusion method for assessment of hemocoagulation tissue factor release reaction. He comes to a conclusion that the diagnosis may become objective, rapid, reliable, and accurate if biophysical characteristics of the hemostasis are investigated, their informative value assessed, and measuring equipment for hematologic laboratories designed and commercially produced.

[Pathology of the reproductive apparatus of cells under the action of remantadine and deitiforin].

The antiviral effect of chemical agents remantadine and deutephorine on the reproductive apparatus of MDCK-cells was studied. It was established that the action of the chemical agents during 3-4 days induced enhancement in pathologically transformed mitoses. This enhancement was in direct proportion to the doses used and to the cultivation time.

[A photodynamic method of studying hemocoagulation].

Herein are offered some principles, photodynamic method and the specialised unit (photocoagulograph) for investigation of the optical and rheological properties of the coagulated substrate. On the basis of the results of recalcified plasma, rich in thrombocytes, the quantitative parameters for description of component hemocoagulation phases are offered, i.e.