Loss of SMAD1 in acute myeloid leukemia with and fusion genes.

Introduction: -rearrangements define a subclass of acute leukemias characterized by a distinct gene expression signature linked to the dysfunctional oncogenic fusion proteins arising from various chromosomal translocations involving the (also known as ) gene. Research on the disease pathomechanism in -rearranged acute leukemias has mainly focused on the upregulation of the stemness-related genes of the -family and their co-factor .

Results: Here we report the and fusion gene-dependent downregulation of , a TGF-β signaling axis transcription factor.

Impact of irradiation conditions on therapy of Lewis lung carcinoma in mice using glucose-ethylenediamine carbon dots.

Background: nowadays, the photoacoustic imaging is in the mainstream of cancer theranostics. In this study the nanoparticles with previously proven photoacoustic imaging properties, i.e.

Synthesis of Fused sp-Enriched Imidazoles.

A synthetic approach to imidazoles annulated to saturated six-membered cycles featuring S, SO, NH, NCbz was developed. It was achieved by combining the Neber rearrangement and the Marckwald reaction. The Neber rearrangement applied to cyclic ketones allowed us to prepare in hundred gram quantities previously unknown α-amino ketones.

Size dependent properties of Gd-free versus Gd-doped carbon dots for bioimaging application.

Gd- free carbon dots (CDs) were synthesized by one-step solvothermal method using urea, citric acid and 3-(trifluoromethyl)aniline as precursors. Additionally, Gd-doped CDs were prepared by incorporating gadolinium chloride (Gd ions) into the synthesis. Size selection of the purified CDs was achieved through filter membranes ranging from 3 kDa to 100 kDa.

Polyvinyl chloride microplastics and drought co-exposure alter rice growth by affecting metabolomics and proteomics.

Microplastics, interacting with drought stress, have become threat to crops by altering soil environment. Currently, the effect of combined microplastic and drought stress on crop growth remain poorly understood. In this work, the mechanism of multi-stress responses was investigated under the exposure of polvinylchloride microplastic (PV) and drought (D) individually and in combination (DPV) on rice varieties Hanyou73 and Q280 through proteomics and metabolomic analysis.