Publications by authors named "V F Haug"

Article Synopsis
  • The Prime-2-CoV_Beta is a new COVID-19 vaccine designed to target the SARS-CoV-2 spike and nucleocapsid antigens, and was tested in a phase I clinical trial involving 60 healthy adults in Germany from June 2022 to June 2023.
  • The trial showed that the vaccine had a good safety profile with only mild to moderate side effects, such as pain at the injection site, fatigue, and headache, and no serious adverse events were reported.
  • Immunization resulted in strong immune responses, particularly at higher doses, leading to significant increases in antibodies against SARS-CoV-2 and its variants, indicating the vaccine's potential for broader protection
View Article and Find Full Text PDF

Introduction: Early wound coverage is one of the most essential factors influencing the survival of extensively burned patients, especially those with a total body surface area (TBSA) burned greater than 50 %. In patients with limited donor sites available for autografting, techniques such as the Meek micrograft procedure or cultured epidermal allografts (CEA) have proven to be viable alternatives. In this systematic review and meta-analysis, we analyzed the outcomes of different wound coverage techniques in patients with massive burn injuries ≥ 50 % TBSA in the past 17 years.

View Article and Find Full Text PDF
Article Synopsis
  • This study investigates postoperative outcomes across different racial and ethnic groups to identify disparities and compare them with socioeconomic factors using a large registry dataset from the American College of Surgeons.
  • The research analyzed over 7 million patients, highlighting that White, Asian, and Native Hawaiian or Pacific Islander patients generally have better surgical outcomes than Black or African American and American Indian or Alaska Native patients.
  • Findings indicate significant disparities in health outcomes linked to race, with socioeconomic factors such as wealth and healthcare access playing a crucial role; further research is needed to understand and address these issues.
View Article and Find Full Text PDF

Background: With advancements in burn treatment and intensive care leading to decreased mortality rates, a growing cohort of burn survivors is emerging. These individuals may be susceptible to frailty, characterized by reduced physiological reserve and increased vulnerability to stressors commonly associated with aging, which significantly complicates their recovery process. To date, no study has investigated burns as a potential risk factor for frailty.

View Article and Find Full Text PDF

Introduction: The functional decline seen in frail patients is associated with significant morbidity and mortality. The modified frailty index 5 (mFI-5) score is an accepted risk predictor score in surgery. Hypoalbuminemia has been correlated with poor postoperative outcomes.

View Article and Find Full Text PDF