Publications by authors named "V F Capaldi"
Article Synopsis
- Traumatic brain injury (TBI) is common in veterans and is linked to various long-term sleep-wake disorders (SWD) that are not fully understood, which complicates diagnosis and treatment.
- A literature review identified gaps in knowledge regarding the pathophysiology of TBI-related sleep issues, compared them with post-traumatic stress disorder sleep disturbances, and highlighted the importance of biomarkers and treatment strategies.
- The conclusion stresses that a better understanding of the scientific basis for TBI and its impact on sleep is needed, focusing on biomarkers and neuroimaging to improve diagnosis and therapy in affected veterans.
Background And Objectives: Insomnia affects about one-third of patients with traumatic brain injury and is associated with worsened outcomes after injury. We hypothesized that higher levels of plasma neuroinflammation biomarkers at the time of TBI would be associated with worse 12-month insomnia trajectories.
Methods: Participants were prospectively enrolled from 18 level-1 trauma centers participating in the Transforming Research and Clinical Knowledge in Traumatic Brain Injury study from February 26, 2014, to August 8, 2018.
Article Synopsis
- The study focuses on improving treatment for military personnel suffering from insomnia by using a machine learning model to predict responses to cognitive behavioral therapy for insomnia (CBT-I).
- The model analyzed data from 1,449 US Army soldiers and achieved a prediction accuracy of about 60%, identifying significant predictors like insomnia severity and suicidal ideation.
- The results suggest that using this model could help target individuals who are more likely to benefit from CBT-I, promoting a personalized approach to insomnia treatment in military settings.