[Surgical treatment of acquired defects and ruptures of interventricular septum].

Surgical repair of posttraumatic ventricular septal defects, aortic-right ventricular fistulas and postinfarction ruptures of interventricular septum was carried out in 15 patients aged 18-75 years. Methods of radical correction included suturing, plastic repair with synthetic and autopericardial patches, and amputation of cardiac apex. Procedures were performed 14 days - 12 months after myocardial infarction and 1-12 months after penetrating knife wounds of the chest and the heart.

[The surgical results in postinfarct aneurysms of the left ventricule and in coronary artery lesions].

In 1992-1997 66 patients with ischemic heart disease and postmyocardial infarction aneurysms in the left ventricle in association with 1 to 6 coronary arteries' lesion underwent surgical intervention when aneurysm elimination operations were accompanied by shunting of 1 to 6 arteries, which resulted in a better contractile ability of the ventricle and load tolerance. As compared with the reference literature data the lethality rate reduced by 2.4 times.

[Experimental and clinical study of the effectiveness of the combined use of anticonvulsants and tranquilizers in epilepsy].

Using experimental and clinical methods, the authors studied the efficacy of combined use of anticonvulsants (phenobarbital, hexamidine, chloracon, trimetin, benzonal, diphenylhydantoin, carbamazepine) and tranquilizers (diazepam, chlordiazepoxide, meprotan, trioxazine, mebicar) in epilepsy treatment. The experimental findings showed that 13 combinations of the above drugs had a synergic effect. Five of these combinations (hexamidine-chlordiazepoxide, benzonal-chlordiazepoxide, phenobarbital-diazepam, phenobarbital-trioxazine, and phenobarbital-mebicar also proved clinically more effective than the use of anticonvulsants alone.

[Effect of anticonvulsants on the psychotropic activity of tranquilizers in their joint use in an experiment].

Effects of anticonvulsants (phenobarbital, hexamidine, benzonal, difenin, chloracon, trimetin, carbamazepine) on the psychotropic activity of tranquillizers (diazepam, chlordiazepoxide, meprotan, trioxazine, mebicar) were studied in experiments on mice and rats. Thirteen combinations were studied by using corazol test, "open field" and elementary-defensive conditioned response technique. According to all three tests the psychotropic activity was enhanced to the greatest degree by administration of hexamidine in combination with chlordiazepoxide.