Publications by authors named "V E Tarasova"
The research relevance is determined by the need for rational use of limited resources in the healthcare sector and the importance of implementing the results of scientific research into medical practice to improve the quality of medical care. The study aims to identify key criteria and develop a system for evaluating clinical trials to prioritise the most promising areas based on their practical applicability in healthcare. The expert evaluation method of 17 research projects in the field of clinical medicine funded by government grants, involving 37 experts, was used to achieve the objective.
View Article and Find Full Text PDFEvaluation of an incidentally discovered indeterminate thyroid nodule (TN) in a previously healthy 59-year female led to diagnosis of thyroid paraganglioma (TPGL) and subsequently hereditary succinate dehydrogenase complex subunit D (-related multifocal head and neck paragangliomas (PGLs). An ultrasound-guided fine needle aspiration (FNA) biopsy of the 1.7-cm TN was nondiagnostic and core biopsy was suspicious for papillary thyroid carcinoma.
View Article and Find Full Text PDFArticle Synopsis
- - The text discusses the challenges in treating thyroid cancer due to limited targeted therapies and the need for identifying specific genomic abnormalities, with plasma-based ctDNA sequencing emerging as a valuable detection method.
- - A study analyzing 1,094 thyroid cancer patients utilized Guardant360 plasma-NGS to find genomic alterations across various subtypes, revealing that 78.3% had one or more mutations, with significant findings in different cancer types.
- - The analysis showed that mutations in the gene were prevalent across various thyroid cancer types, particularly in anaplastic and papillary thyroid cancers, and indicated that the blood tumor mutation burden was notably higher in anaplastic thyroid cancer.
The head and neck region is one of the anatomic sites commonly afflicted by cancer, with ~1.5 million new diagnoses reported worldwide in 2020 alone. Remarkable progress has been made in understanding the underlying disease mechanisms, personalizing care based on each tumor's individual molecular characteristics, and even therapeutically exploiting the inherent vulnerabilities of these neoplasms.
View Article and Find Full Text PDFObjective: To determine the proportion of aspirates reclassified into each Bethesda category and to assess the rates of malignancy in each of them on repeat fine-needle aspiration biopsy (RFNA) following an AUS/FLUS diagnosis.
Design: Systematic review and meta-analysis.
Methods: On February 2019, Pubmed/MEDLINE, EMBASE, WoS, and the Cochrane Library were searched for articles published from January 1, 2007.